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Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum
Chen, Xian-Qiang1; Lin, Li-Gen1; Zhao, Jing1,2; Chen, Ling-Xiao1; Tang, Yu-Ping3; Luo, De-Lun2; Li, Shao-Ping1
2018-06
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:6
Abstract

Ganoderma resinaceum has been used as an ethnomedicine for lowering blood sugar. To clarify the bioactive chemical constituents contributing to lower blood sugar, chemical investigation on the fruiting bodies of Ganoderma resinaceum was conducted by chromatographic techniques, and led to the isolation of 14 compounds. Their structures were elucidated as triterpenoid lactones (1-4 and 8) and ganoderma acids (5-7 and 9-14) based on the analysis of extensive spectroscopy (mass spectrometry (MS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)) and comparison with literature data. Compounds 3, 5, 6, and 9-14 were evaluated for alpha-glucosidase inhibitory activity. Compounds 1-7 are new compounds. Compounds 1-4 and 8 were characteristic of an oxaspirolactone moiety, consisting of a five-membered ether ring, a five-membered lactone ring, and a characteristic C-23 spiro carbon. It is rare for natural products that such an oxaspirolactone moiety occurred in the lanostane-type triterpenoids. Compounds 5-7 and 9-14 may be important intermediates of the biosynthetic pathways of 1-4 and 8. Compounds 1 and 2 showed more potent inhibitory activity against alpha-glucosidase compared with the positive control drug acarbose with IC50 value of 0.75 +/- 0.018 mM and 1.64 +/- 0.022 mM, respectively.

KeywordGanoderma Resinaceum Triterpenoid Triterpenoid Lactone Oxaspirolactone Alpha-glucosidase Inhibitory Activity
DOI10.3390/molecules23061391
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000435875400152
PublisherMDPI
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi, Shao-Ping
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
2.Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611730, China.
3.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Xian-Qiang,Lin, Li-Gen,Zhao, Jing,et al. Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum[J]. MOLECULES,2018,23(6).
APA Chen, Xian-Qiang.,Lin, Li-Gen.,Zhao, Jing.,Chen, Ling-Xiao.,Tang, Yu-Ping.,...&Li, Shao-Ping.(2018).Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum.MOLECULES,23(6).
MLA Chen, Xian-Qiang,et al."Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum".MOLECULES 23.6(2018).
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