UM
Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum
Chen, Xian-Qiang; Lin, Li-Gen; Zhao, Jing; Chen, Ling-Xiao; Tang, Yu-Ping; Luo, De-Lun; Li, Shao-Ping
2018-06
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:6
AbstractGanoderma resinaceum has been used as an ethnomedicine for lowering blood sugar. To clarify the bioactive chemical constituents contributing to lower blood sugar, chemical investigation on the fruiting bodies of Ganoderma resinaceum was conducted by chromatographic techniques, and led to the isolation of 14 compounds. Their structures were elucidated as triterpenoid lactones (1-4 and 8) and ganoderma acids (5-7 and 9-14) based on the analysis of extensive spectroscopy (mass spectrometry (MS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)) and comparison with literature data. Compounds 3, 5, 6, and 9-14 were evaluated for alpha-glucosidase inhibitory activity. Compounds 1-7 are new compounds. Compounds 1-4 and 8 were characteristic of an oxaspirolactone moiety, consisting of a five-membered ether ring, a five-membered lactone ring, and a characteristic C-23 spiro carbon. It is rare for natural products that such an oxaspirolactone moiety occurred in the lanostane-type triterpenoids. Compounds 5-7 and 9-14 may be important intermediates of the biosynthetic pathways of 1-4 and 8. Compounds 1 and 2 showed more potent inhibitory activity against alpha-glucosidase compared with the positive control drug acarbose with IC50 value of 0.75 +/- 0.018 mM and 1.64 +/- 0.022 mM, respectively.
KeywordGanoderma resinaceum triterpenoid triterpenoid lactone oxaspirolactone alpha-glucosidase inhibitory activity
DOI10.3390/molecules23061391
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000435875400152
PublisherMDPI
The Source to ArticleWOS
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Chen, Xian-Qiang,Lin, Li-Gen,Zhao, Jing,et al. Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum[J]. MOLECULES,2018,23(6).
APA Chen, Xian-Qiang.,Lin, Li-Gen.,Zhao, Jing.,Chen, Ling-Xiao.,Tang, Yu-Ping.,...&Li, Shao-Ping.(2018).Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum.MOLECULES,23(6).
MLA Chen, Xian-Qiang,et al."Isolation, Structural Elucidation, and alpha-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum".MOLECULES 23.6(2018).
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