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Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations
Wei Xiong1; Guan Ding Zhao1; Xunqing Yin2; Ke Gang Linghu1; John M.T. Chu3; Gordon T.C. Wong3; Haifeng Li2; Hua Yu1,4,5; Yi Tao Wang1
2019-01-15
Source PublicationCarbohydrate Polymers
Volume204Pages:89-96
Abstract

Chitosan (CS), a nature-derived polysaccharide, is a promising nano-carrier material with good biocompatibility and biodegradability. However, the biomedical applications of CS are hindered because of its poor aqueous solubility. To circumvent this drawback, a series of Brij-grafted-chitosan copolymers (BCs) with various grafting degree of Brij-S20 were first developed and reported. The results indicated that the water solubility of BCs (from 9.13 to 9.54 mg/mL) were much higher than that of CS (0.32 mg/mL), due to the broken intra- and/or inter-molecular hydrogen bonds and the decreased initial crystallinity in BCs. The amphiphilic structure of BCs presented lower critical micelle concentration (0.116–0.376 mg/mL) thus facilitating its self-aggregation into micelles for drug encapsulation. Moreover, BCs markedly enhanced the intracellular uptake of rhodamine-123 in MDCK-MDR1 cells. This inhibition on Pgp-mediated efflux was also confirmed by confocal microscopy. In conclusion, BCs could be further developed as polymeric nano-carriers for those drugs with Pgp-mediated efflux.

KeywordChitosan Brij-s20 Solubility P-glycoprotein Drug Efflux
DOIhttp://doi.org/10.1016/j.carbpol.2018.10.007
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000448147100011
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHua Yu
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China
2.Institute of Applied Physics and Materials Engineering, University of Macau, Macao SAR, China
3.Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
4.Hong Kong Baptist University Shenzhen Research Center, Shenzhen, Guangdong, China
5.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wei Xiong,Guan Ding Zhao,Xunqing Yin,et al. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations[J]. Carbohydrate Polymers,2019,204:89-96.
APA Wei Xiong.,Guan Ding Zhao.,Xunqing Yin.,Ke Gang Linghu.,John M.T. Chu.,...&Yi Tao Wang.(2019).Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations.Carbohydrate Polymers,204,89-96.
MLA Wei Xiong,et al."Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations".Carbohydrate Polymers 204(2019):89-96.
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