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The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910
Wang C.-M.1; Jia Z.-N.3; Zheng R.-L.1
2007-02-01
Source PublicationPlanta Medica
ISSN00320943
Volume73Issue:2Pages:180-184
AbstractUsing the MTT assay and the telomeric repeat amplification protocol (TRAP)-based PCR-ELISA assay, the cytotoxicity and telomerase inhibiting ability of 17 sesquiterpenes (extracted from Chinese herbs) were tested in the human ovarian cancer cell line HO-8910. The results indicated that seven sesquiterpenes inhibited cell proliferation without having an effect on telomerase activity; two sesquiterpenes inhibited neither cell proliferation nor telomerase activity; and the other eight sesquiterpenes inhibited both cell proliferation and telomerase activity to a certain extent. Without exception, none of these 17 sesquiterpenes could only inhibit telomerase activity without inhibiting cell proliferation. This indicated that the telomerase inhibiting activity is not a universal mechanism for all anticancer drugs but is only one of several possible mechanisms. The structure-activity relationships of 5 groups of sesquiterpenes are also discussed. This study may help to develop anticancer drugs. © Georg Thieme Verlag KG Stuttgart.
DOI10.1055/s-2006-957080
URLView the original
Language英語
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Cited Times [WOS]:31   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Lanzhou University
2.E-Institutes of Shanghai Municipal Education Commission
3.State Key Laboratory of Applied Organic Chemistry
Recommended Citation
GB/T 7714
Wang C.-M.,Jia Z.-N.,Zheng R.-L.. The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910[J]. Planta Medica,2007,73(2):180-184.
APA Wang C.-M.,Jia Z.-N.,&Zheng R.-L..(2007).The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910.Planta Medica,73(2),180-184.
MLA Wang C.-M.,et al."The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910".Planta Medica 73.2(2007):180-184.
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