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Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles
Qu, Man1; Xu, Kangni1; Li, Yunhui2; Wong, Garry3; Wang, Dayong1
2018-12
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume643Pages:119-126
Abstract

In this study, we employed Caenorhabditis elegans with acs-22 mutation to examine the in vivo effect of functional deficit in intestinal barrier on toxicity and translocation of nanopolystyrene particles. Mutation of acs-22 leads to deficit in intestinal barrier. After prolonged exposure, nanopolystyrene particles at concentrations >= 1 mu g/L could cause toxicity on acs-22 mutant nematodes. acs-22 mutation resulted in translocation of nanopolystyrene particles into targeted organs through intestinal barrier in nanopolystyrene particles (1 mu g/L) exposed nematodes. After prolonged exposure, nanopolystyrene particles (1 mu g/L) dysregulated expressions of some genes required for the control of oxidative stress and activated expression of Nrf signaling pathway. Therefore, under certain pathological conditions, our results suggest the potential toxicity of nanoplastic particles at predicted environmental concentration on organisms after long-term exposure. (C) 2018 Elsevier B.V. All rights reserved.

KeywordIntestinal Barrier Translocation Nanopolystyrene Particles Caenorhabditis Elegans
DOIhttps://doi.org/10.1016/j.scitotenv.2018.06.173
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000444625900013
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang, Dayong
Affiliation1.Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Medical School, Southeast University, Nanjing 210009, China
2.School of Public Health, Southeast University, Nanjing 210009, China
3.Faculty of Health Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Qu, Man,Xu, Kangni,Li, Yunhui,et al. Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,643:119-126.
APA Qu, Man,Xu, Kangni,Li, Yunhui,Wong, Garry,&Wang, Dayong.(2018).Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles.SCIENCE OF THE TOTAL ENVIRONMENT,643,119-126.
MLA Qu, Man,et al."Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles".SCIENCE OF THE TOTAL ENVIRONMENT 643(2018):119-126.
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