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APTES-modified nanosilica - But neither APTES nor nanosilica - Inhibits endothelial cell growth via arrest of cell cycle at G1 phase
Niu Y.2; Chan W.-I.2; Yu N.3; Gan J.1; Dong L.1; Wang C.2
2015-11-01
Source PublicationJournal of Biomaterials Applications
ISSN15308022 08853282
Volume30Issue:5Pages:608-617
AbstractThe adverse effects of nanomaterials on the living system have attracted considerable attention in the past few years. Such effects may come from either the core nanomaterials or the chemical agents used to modify the nanomaterials - the latter being largely overlooked. In a free form, these modifying agents might have little impact on living cells; however, they may exhibit distinct biological effects when they assemble into a larger dimension. Here, we report that (3-aminopropyl)triethoxysilane - a small molecule compound ubiquitously employed to functionalise nanosilica surface - could decrease the viability of human umbilical vein endothelial cells when it was grafted onto the nanosilica surface. However, intriguingly, such effect was not found in 3-aminopropyl)triethoxysilane itself, the unmodified silica nanoparticles or the 3-aminopropyl)triethoxysilane-modified microparticles. Change of surface charge was excluded as a cause and apoptosis was not observed. Nevertheless, the 3-aminopropyl)triethoxysilane-modified nanoparticles could exclusively arrest cell cycle at G1 phase. Our findings suggest that substances could gain 'new' functions at the nanoscale, which may not be found in their larger or smaller counterparts. Understanding of such effects will provide critical insights for better evaluation and thus safer use of nanomaterials, in particular those having been pre-modified with other agents.
Keyword(3-aminopropyl)triethoxysilane cell cycle endothelial cell Nanotoxicity silicon dioxide
DOI10.1177/0885328215598497
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Nanjing University
2.University of Macau
3.National Dental Centre of Singapore
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Niu Y.,Chan W.-I.,Yu N.,et al. APTES-modified nanosilica - But neither APTES nor nanosilica - Inhibits endothelial cell growth via arrest of cell cycle at G1 phase[J]. Journal of Biomaterials Applications,2015,30(5):608-617.
APA Niu Y.,Chan W.-I.,Yu N.,Gan J.,Dong L.,&Wang C..(2015).APTES-modified nanosilica - But neither APTES nor nanosilica - Inhibits endothelial cell growth via arrest of cell cycle at G1 phase.Journal of Biomaterials Applications,30(5),608-617.
MLA Niu Y.,et al."APTES-modified nanosilica - But neither APTES nor nanosilica - Inhibits endothelial cell growth via arrest of cell cycle at G1 phase".Journal of Biomaterials Applications 30.5(2015):608-617.
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