UM  > 中華醫藥研究院
Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy
He W.1; Liang P.1; Guo G.1; Huang Z.1; Niu Y.2; Dong L.1; Wang C.2; Zhang J.1
2016-04-14
Source PublicationScientific Reports
ISSN20452322
Volume6
Abstract

Our evolving understandings of cell-material interactions provide insights for using polymers to modulate cell behaviour that may lead to therapeutic applications. It is known that in certain cancers, myeloid-derived suppressor cells (MDSCs) play vital roles in promoting tumour progression, chiefly because of their 'alternatively activated' (or M2) phenotype that orchestrates immunosuppression. In this study, we demonstrated that two cationic polymers - cationic dextran (C-dextran) and polyethyleneimine (PEI) - could directly remodel these cells into an anti-tumour, 'classically activated' (or M1) phenotype, thereby stimulating these cells to express tumouricidal cytokines, reactivating the T cell functions, and prolonging the lifespan of the mice model. Our investigations with knock-out mice further indicate that the functions of these cationic polymers require the involvement of toll-like receptor 4-mediated signalling. Taken together, our study suggests that these cationic polymers can effectively and directly re-polarize MDSCs from an immunosuppressive characteristic to an anti-tumour phenotype, leading to successful restoration of immune surveillance in the tumour microenvironment and elimination of tumour cells. Our findings may have immediate impact on further development of polymer-based therapeutics for cancer immunotherapy.

DOI10.1038/srep24506
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000374042000003
Fulltext Access
Citation statistics
Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Nanjing University
2.University of Macau
Recommended Citation
GB/T 7714
He W.,Liang P.,Guo G.,et al. Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy[J]. Scientific Reports,2016,6.
APA He W..,Liang P..,Guo G..,Huang Z..,Niu Y..,...&Zhang J..(2016).Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy.Scientific Reports,6.
MLA He W.,et al."Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy".Scientific Reports 6(2016).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He W.]'s Articles
[Liang P.]'s Articles
[Guo G.]'s Articles
Baidu academic
Similar articles in Baidu academic
[He W.]'s Articles
[Liang P.]'s Articles
[Guo G.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He W.]'s Articles
[Liang P.]'s Articles
[Guo G.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.