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Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection
Huang Z.1; Gan J.1; Long Z.1; Guo G.1; Shi X.1; Wang C.2; Zang Y.1; Ding Z.1; Chen J.1; Zhang J.1; Dong L.1
2016-06-01
Source PublicationBiomaterials
ISSN18785905 01429612
Volume90Pages:72-84
Abstract

Both tumor associated macrophages (TAMs) and tumor infiltrating dendritic cells (TIDCs) are important components in the tumor microenvironment that mediate tumor immunosuppression and promote cancer progression. Targeting these cells and altering their phenotypes may become a new strategy to recover their anti-tumor activities and thereby restore the local immune surveillance against tumor. In this study, we constructed a nucleic acid delivery system for the delivery of let-7b, a synthetic microRNA mimic. Our carrier has an affinity for the mannose receptors on TAMs/TIDCs and is responsive to the low-pH tumor microenvironment. The delivery of let-7b could reactivate TAMs/TIDCs by acting as a TLR-7 agonist and suppressing IL-10 production in vitro. In a breast cancer mouse model, let-7b delivered by this system efficiently reprogrammed the functions of TAMs/TIDCs, reversed the suppressive tumor microenvironment, and inhibited tumor growth. Taken together, this strategy, designed based upon TAMs/TIDCs-targeting delivery and the dual biological functions of let-7b (TLR-7 ligand and IL-10 inhibitor), may provide a new approach for cancer immunotherapy.

KeywordCancer Immunotherapy Let-7b Targeted Delivery Tumor-associated Macrophage Tumor-infiltrating Dendritic Cell
DOI10.1016/j.biomaterials.2016.03.009
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000374618100007
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Citation statistics
Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Nanjing University
2.University of Macau
Recommended Citation
GB/T 7714
Huang Z.,Gan J.,Long Z.,et al. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection[J]. Biomaterials,2016,90:72-84.
APA Huang Z..,Gan J..,Long Z..,Guo G..,Shi X..,...&Dong L..(2016).Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection.Biomaterials,90,72-84.
MLA Huang Z.,et al."Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection".Biomaterials 90(2016):72-84.
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