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Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy
Zhu Q.1; Qi H.1; Long Z.1; Liu S.1; Huang Z.1; Zhang J.1; Wang C.2; Dong L.1
2016-06-23
Source PublicationScientific Reports
ISSN20452322
Volume6
AbstractThe difficulty of controlling drug release at an intracellular level remains a key challenge for maximising drug safety and efficacy. We demonstrate herein a new, efficient and convenient approach to extracellularly control the intracellular release of doxorubicin (DOX), by designing a delivery system that harnesses the interactions between the system and a particular set of cellular machinery. By simply adding a small-molecule chemical into the cell medium, we could lower the release rate of DOX in the cytosol, and thereby increase its accumulation in the nuclei while decreasing its presence at mitochondria. Delivery of DOX with this system effectively prevented DOX-induced mitochondria damage that is the main mechanism of its toxicity, while exerting the maximum efficacy of this anti-cancer chemotherapeutic agent. The present study sheds light on the design of drug delivery systems for extracellular control of intracellular drug delivery, with immediate therapeutic implications.
DOI10.1038/srep28596
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Nanjing University
2.University of Macau
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GB/T 7714
Zhu Q.,Qi H.,Long Z.,et al. Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy[J]. Scientific Reports,2016,6.
APA Zhu Q..,Qi H..,Long Z..,Liu S..,Huang Z..,...&Dong L..(2016).Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy.Scientific Reports,6.
MLA Zhu Q.,et al."Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy".Scientific Reports 6(2016).
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