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Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor
Ye R.D.; Cavanagh S.L.; Quehenberger O.; Prossnitz E.R.; Cochrane C.G.
1992-04-30
Source PublicationBiochemical and Biophysical Research Communications
ISSN10902104 0006291X
Volume184Issue:2Pages:582-589
AbstractA cDNA of 1650 base pairs was isolated by screening an HL-60 granulocyte library with an N-formyl peptide receptor (NFPR) cDNA probe under low stringency conditions. The cDNA encodes a protein of 351 amino acids tentatively named FPR2, with a calculated molecular weight of 39 kDa. Sequence analysis revealed that FPR2 is 69% identical in sequence to the human NFPR and shares extensive homology to several other chemoattractant receptors. FPR2 expressed in transfected cells mediated formyl peptide-stimulated calcium mobilization at micromolar concentrations of ligand. FPR2 messenger is detected in granulocytic HL-60 cells, but not in undifferentiated HL-60 cells. These findings suggest that FPR2 is a novel receptor for formyl peptide ligand and a new member of the chemoattractant receptor gene family. © 1992.
DOI10.1016/0006-291X(92)90629-Y
URLView the original
Language英語
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Document TypeJournal article
CollectionPersonal research not belonging to the institution
AffiliationScripps Research Institute
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GB/T 7714
Ye R.D.,Cavanagh S.L.,Quehenberger O.,et al. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor[J]. Biochemical and Biophysical Research Communications,1992,184(2):582-589.
APA Ye R.D.,Cavanagh S.L.,Quehenberger O.,Prossnitz E.R.,&Cochrane C.G..(1992).Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.Biochemical and Biophysical Research Communications,184(2),582-589.
MLA Ye R.D.,et al."Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor".Biochemical and Biophysical Research Communications 184.2(1992):582-589.
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