UM
The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function
Prossnitz E.R.; Ye R.D.
1997-08-22
Source PublicationPharmacology and Therapeutics
ISSN01637258
Volume74Issue:1Pages:73-102
AbstractN-formyl peptides, such as fMet-Leu-Phe, are one of the most potent chemoattractants for phagocytic leukocytes. The interaction of N-formyl peptides with their specific cell surface receptors has been studied extensively and used as a model system for the characterization of G-protein- coupled signal transduction in phagocytes. The cloning of the N-formyl peptide receptor cDNA from several species and the identification of homologous genes have allowed detailed studies of structural and functional aspects of the receptor. Recent findings that the receptor is expressed in nonhematopoietic cells and that nonformylated peptides can activate the receptor suggest potentially novel functions and the existence of additional ligands for this receptor.
KeywordChemoattractants G-protein-coupled receptor Inflammation N-formyl peptide N-formyl peptide receptor
DOI10.1016/S0163-7258(96)00203-3
URLView the original
Language英語
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Cited Times [WOS]:211   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationScripps Research Institute
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GB/T 7714
Prossnitz E.R.,Ye R.D.. The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function[J]. Pharmacology and Therapeutics,1997,74(1):73-102.
APA Prossnitz E.R.,&Ye R.D..(1997).The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function.Pharmacology and Therapeutics,74(1),73-102.
MLA Prossnitz E.R.,et al."The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function".Pharmacology and Therapeutics 74.1(1997):73-102.
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