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Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression
Deng J.1; Wang X.1; Qian F.2; Vogel S.2; Xiao L.1; Ranjan R.1; Park H.1; Karpurapu M.1; Ye R.D.2; Park G.Y.1; Christman J.W.1
2012-06-01
Source PublicationJournal of Immunology
ISSN00221767 15506606
Volume188Issue:11Pages:5734-5740
AbstractReactive oxygen species (ROS) generated by NADPH oxidase are generally known to be proinflammatory, and it seems to be counterintuitive that ROS play a critical role in regulating the resolution of the inflammatory response. However, we observed that deficiency of the p47 component of NADPH oxidase in macrophages was associated with a paradoxical accentuation of inflammation in a whole animal model of noninfectious sepsis induced by endotoxin. We have confirmed this observation by interrogating four separate in vivo models that use complementary methodology including the use of p47 mice, p47 bone marrow chimera mice, adoptive transfer of macrophages from p47phox mice, and an isolated perfused lung edema model that all point to a relationship between excessive acute inflammation and p47 deficiency in macrophages. Mechanistic data indicate that ROS deficiency in both cells and mice results in decreased production of IL-10 in response to treatment with LPS, at least in part, through attenuation of the Akt-GSK3-β signal pathway and that it can be reversed by the administration of rIL-10. Our data support the innovative concept that generation of ROS is essential for counterregulation of acute lung inflammation.
DOI10.4049/jimmunol.1101323
URLView the original
Language英語
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Cited Times [WOS]:33   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.University of Illinois at Chicago
2.University of Illinois College of Medicine
3.VA Medical Center
Recommended Citation
GB/T 7714
Deng J.,Wang X.,Qian F.,et al. Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression[J]. Journal of Immunology,2012,188(11):5734-5740.
APA Deng J..,Wang X..,Qian F..,Vogel S..,Xiao L..,...&Christman J.W..(2012).Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression.Journal of Immunology,188(11),5734-5740.
MLA Deng J.,et al."Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression".Journal of Immunology 188.11(2012):5734-5740.
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