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Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient
Liu X.1; Yang T.4; Suzuki K.2; Tsukita S.2; Ishii M.3; Zhou S.4; Wang G.1; Cao L.1; Qian F.1; Taylor S.1; Oh M.-J.1; Levitan I.1; Ye R.D.1; Carnegie G.K.1; Zhao Y.4; Malik A.B.1; Xu J.1
2015
Source PublicationJournal of Experimental Medicine
ISSN15409538 00221007
Volume212Issue:2Pages:267-280
AbstractNeutrophils respond to invading bacteria by adopting a polarized morphology, migrating in the correct direction, and engulfing the bacteria. How neutrophils establish and precisely orient this polarity toward pathogens remains unclear. Here we report that in resting neutrophils, the ERM (ezrin, radixin, and moesin) protein moesin in its active form (phosphorylated and membrane bound) prevented cell polarization by inhibiting the small GTPases Rac, Rho, and Cdc42. Attractant-induced activation of myosin phosphatase deactivated moesin at the prospective leading edge to break symmetry and establish polarity. Subsequent translocation of moesin to the trailing edge confined the formation of a prominent pseudopod directed toward pathogens and prevented secondary pseudopod formation in other directions. Therefore, both moesin-mediated inhibition and its localized deactivation by myosin phosphatase are essential for neutrophil polarization and effective neutrophil tracking of pathogens.
DOI10.1084/jem.20140508
URLView the original
Language英語
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.University of Illinois at Chicago
2.Laboratory of Biological Science
3.Osaka University
4.Institute of Zoology Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu X.,Yang T.,Suzuki K.,et al. Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient[J]. Journal of Experimental Medicine,2015,212(2):267-280.
APA Liu X..,Yang T..,Suzuki K..,Tsukita S..,Ishii M..,...&Xu J..(2015).Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient.Journal of Experimental Medicine,212(2),267-280.
MLA Liu X.,et al."Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient".Journal of Experimental Medicine 212.2(2015):267-280.
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