UM
Pivotal role of mitogen-activated protein Kinase-activated protein Kinase 2 in inflammatory pulmonary diseases
Qian F.3; Deng J.2; Wang G.1; Ye R.D.3; Christman J.W.2
2016-06-01
Source PublicationCurrent Protein and Peptide Science
ISSN18755550 13892037
Volume17Issue:4Pages:332-342
AbstractMitogen-activated protein kinase (MAPK)-activated protein kinase (MK2) is exclusively regulated by p38 MAPK in vivo. Upon activation of p38 MAPK, MK2 binds with p38 MAPK, leading to phosphorylation of TTP, Hsp27, Akt, and Cdc25 that are involved in regulation of various essential cellular functions. In this review, we discuss current knowledge about molecular mechanisms of MK2 in regulation of TNF-α production, NADPH oxidase activation, neutrophil migration, and DNA-damage-induced cell cycle arrest which are involved in the molecular pathogenesis of acute lung injury, pulmonary fibrosis, and non-small-cell lung cancer. Collectively current and emerging new information indicate that developing MK2 inhibitors and blocking MK2-mediated signal pathways are potential therapeutic strategies for treatment of inflammatory and fibrotic lung diseases and lung cancer.
KeywordAcute lung injury Inflammation Lung cancer MAPK MK2 Pulmonary fibrosis
DOI10.2174/1389203716666150629121324
URLView the original
Language英語
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.XuZhou Medical University
2.Ohio State University
3.Shanghai Jiao Tong University
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GB/T 7714
Qian F.,Deng J.,Wang G.,et al. Pivotal role of mitogen-activated protein Kinase-activated protein Kinase 2 in inflammatory pulmonary diseases[J]. Current Protein and Peptide Science,2016,17(4):332-342.
APA Qian F.,Deng J.,Wang G.,Ye R.D.,&Christman J.W..(2016).Pivotal role of mitogen-activated protein Kinase-activated protein Kinase 2 in inflammatory pulmonary diseases.Current Protein and Peptide Science,17(4),332-342.
MLA Qian F.,et al."Pivotal role of mitogen-activated protein Kinase-activated protein Kinase 2 in inflammatory pulmonary diseases".Current Protein and Peptide Science 17.4(2016):332-342.
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