UM
New biphenantherene and nervogenic acid derivatives from Liparis regnieri Finet and their inhibitory activities against NF-κB activation
Ren J.1; Fan C.1; Guo Y.-G.1; Yan S.-K.1; Ye R.D.1; Zhang Y.1; Jin H.-Z.1; Zhang W.-D.1
2017
Source PublicationTetrahedron
ISSN14645416 00404020
Volume73Issue:12Pages:1611-1617
AbstractA phytochemical investigation of the whole plant of Liparis regnieri Finet led to the isolation of one new biphenantherene (1) and ten new nervogenic acid derivatives (2–11), together with nine known compounds. Their structures were elucidated mainly by extensive analyses of 1D and 2D NMR spectroscopic data and chemical reactions. Additionally, for the first time a previously unreported biphenantherene was discovered to effectively suppress TNF-α induced expression of NF-κB-Luc in Hela cells with the ICvalue of 1.80 μM and the structure-activity relationshipwas also discussed.
KeywordBiphenantherene Liparis regnieri Finet Nervogenic acid derivative NF-κB Orchidaceae Phenanthrene
DOI10.1016/j.tet.2017.02.004
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Jiao Tong University
2.Shanghai University of Traditional Chinese Medicine
Recommended Citation
GB/T 7714
Ren J.,Fan C.,Guo Y.-G.,et al. New biphenantherene and nervogenic acid derivatives from Liparis regnieri Finet and their inhibitory activities against NF-κB activation[J]. Tetrahedron,2017,73(12):1611-1617.
APA Ren J..,Fan C..,Guo Y.-G..,Yan S.-K..,Ye R.D..,...&Zhang W.-D..(2017).New biphenantherene and nervogenic acid derivatives from Liparis regnieri Finet and their inhibitory activities against NF-κB activation.Tetrahedron,73(12),1611-1617.
MLA Ren J.,et al."New biphenantherene and nervogenic acid derivatives from Liparis regnieri Finet and their inhibitory activities against NF-κB activation".Tetrahedron 73.12(2017):1611-1617.
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