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An exploration of traditional Chinese medicinal plants with anti-inflammatory activities
Fan C.; Jin H.-Z.; Wu L.; Zhang Y.; Ye R.D.; Zhang W.; Zhang Y.
2017
Source PublicationEvidence-based Complementary and Alternative Medicine
ISSN17414288 1741427X
Volume2017
AbstractIn a continuing effort to discover more anti-inflammatory medicinal plants in China, the anti-inflammatory activities of 101 extracts from different parts of 84 traditional medicinal plants were evaluated by a panel of in vitro and in vivo assays. Nuclear factor-kappa B (NF-B) inhibitory effects were determined by luciferase assay in stably transfected Hela cells. Cytotoxic activities were assessed using the MTT assay. Inhibitory effects on LPS-induced nitric oxide production and proinflammatory mediators were assessed by Griess reaction and Real-Time PCR analysis, respectively. In vivo anti-inflammatory activities were examined by xylene-induced mice ear edema model. In total, 22 extracts showed promising NF-B inhibitory effects whereas 9 of them did not affect the cell viability. The 9 hit extracts were active in at least one of the subsequently performed in vitro pharmacological test systems. The extract from Hemerocallis minor (root) was selected to perform the in vivo study because it demonstrated significant suppressive effects in all the in vitro assays. Results showed that the extract of Hemerocallis minor (Root) was able to alleviate ear edema effectively in xylene-induced mice ear edema mode. Collectively, our study provides evidence for the potential anti-inflammatory effects of the medicinal plants traditionally used in China. Further phytochemical and pharmacological studies remain to be clarified.
DOI10.1155/2017/1231820
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationShanghai Jiao Tong University
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GB/T 7714
Fan C.,Jin H.-Z.,Wu L.,et al. An exploration of traditional Chinese medicinal plants with anti-inflammatory activities[J]. Evidence-based Complementary and Alternative Medicine,2017,2017.
APA Fan C..,Jin H.-Z..,Wu L..,Zhang Y..,Ye R.D..,...&Zhang Y..(2017).An exploration of traditional Chinese medicinal plants with anti-inflammatory activities.Evidence-based Complementary and Alternative Medicine,2017.
MLA Fan C.,et al."An exploration of traditional Chinese medicinal plants with anti-inflammatory activities".Evidence-based Complementary and Alternative Medicine 2017(2017).
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