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Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy
Zhang, Yuan-Ming1; Zhang, Xiao-Hong1; Zhu, Pan2; Tan, Rong-Hui1; Zhao, Jin-Shun1; Wang, Feng3; Zhang, Jin-Jie4; Yan, Wang5; Xi, Yang1; Wan, Jian-Bo6; Kang, Jing-Xuan7; Zou, Zu-Quan1; Bu, Shi-Zhong1
2018-06
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume45Pages:427-434
Abstract

Although n-3 polyunsaturated fatty acids (PUFAs) exhibit biological activity in many inflammatory diseases, their renoprotective effects against diabetic nephropathy (DN) have been controversial. Here, fat-1 transgenic mice were used to investigate the effects of n-3 PUFA5 on streptozocin (STZ)-induced DN. Fat-1 mice exhibited increased renal n-3 PUFAs and n-3 PUFA-derived lipid mediators, compared to wild type (WT) mice. Endogenous n-3 PUFAs protected STZ-treated fat-1 mice against hyperglycemia-induced renal dysfunction, as reflected by significant decreases in kidney/body weight ratio, urinary protein, blood urea nitrogen levels and creatinine clearance. In addition, endogenous n-3 PUFAs significantly ameliorated hyperglycemia-induced renal damage by modulating E-cadhein expression. It was also found that DN-induced NLRP3 inflammasome activation was attenuated by endogenous n-3 PUFA5 in STZ-treated fat-1 mice. Our findings suggest that endogenous n-3 PUFAs ameliorate DN potentially through the: (i) formation of n-3 lipid mediators, (ii) induction of E-cadherin expression and (iii) inhibition of NLRP3 inflammasome.

KeywordFat-1 N-3 Pufas Nlrp3 Inflammasome Lipid Mediators E-cadherin Diabetic Nephropathy
DOI10.1016/j.jff.2018.04.010
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000434494300049
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZou, Zu-Quan; Bu, Shi-Zhong
Affiliation1.Medical School, Ningbo University, Ningbo, Zhejiang 315211, China
2.Nutrition Department, Mingzhou Hospital, Ningbo, Zhejiang 315199, China
3.Clinical Laboratory, Lihuili Hospital, Ningbo, Zhejiang 315040, China
4.Maritime Faculty, Ningbo University, Ningbo, Zhejiang 315211, China
5.Neurosurgery Department, Second Hospital of Ningbo, Ningbo, Zhejiang 315010, China
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 519000, Macao, China
7.Laboratory for Lipid Medicine and Technology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Recommended Citation
GB/T 7714
Zhang, Yuan-Ming,Zhang, Xiao-Hong,Zhu, Pan,et al. Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy[J]. JOURNAL OF FUNCTIONAL FOODS,2018,45:427-434.
APA Zhang, Yuan-Ming.,Zhang, Xiao-Hong.,Zhu, Pan.,Tan, Rong-Hui.,Zhao, Jin-Shun.,...&Bu, Shi-Zhong.(2018).Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy.JOURNAL OF FUNCTIONAL FOODS,45,427-434.
MLA Zhang, Yuan-Ming,et al."Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy".JOURNAL OF FUNCTIONAL FOODS 45(2018):427-434.
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