UM
Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy
Zhang, Yuan-Ming; Zhang, Xiao-Hong; Zhu, Pan; Tan, Rong-Hui; Zhao, Jin-Shun; Wang, Feng; Zhang, Jin-Jie; Yan, Wang; Xi, Yang; Wan, Jian-Bo; Kang, Jing-Xuan; Zou, Zu-Quan; Bu, Shi-Zhong
2018-06
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume45Pages:427-434
AbstractAlthough n-3 polyunsaturated fatty acids (PUFAs) exhibit biological activity in many inflammatory diseases, their renoprotective effects against diabetic nephropathy (DN) have been controversial. Here, fat-1 transgenic mice were used to investigate the effects of n-3 PUFA5 on streptozocin (STZ)-induced DN. Fat-1 mice exhibited increased renal n-3 PUFAs and n-3 PUFA-derived lipid mediators, compared to wild type (WT) mice. Endogenous n-3 PUFAs protected STZ-treated fat-1 mice against hyperglycemia-induced renal dysfunction, as reflected by significant decreases in kidney/body weight ratio, urinary protein, blood urea nitrogen levels and creatinine clearance. In addition, endogenous n-3 PUFAs significantly ameliorated hyperglycemia-induced renal damage by modulating E-cadhein expression. It was also found that DN-induced NLRP3 inflammasome activation was attenuated by endogenous n-3 PUFA5 in STZ-treated fat-1 mice. Our findings suggest that endogenous n-3 PUFAs ameliorate DN potentially through the: (i) formation of n-3 lipid mediators, (ii) induction of E-cadherin expression and (iii) inhibition of NLRP3 inflammasome.
KeywordFat-1 n-3 PUFAs NLRP3 inflammasome Lipid mediators E-cadherin Diabetic nephropathy
DOI10.1016/j.jff.2018.04.010
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000434494300049
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, Yuan-Ming,Zhang, Xiao-Hong,Zhu, Pan,et al. Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy[J]. JOURNAL OF FUNCTIONAL FOODS,2018,45:427-434.
APA Zhang, Yuan-Ming.,Zhang, Xiao-Hong.,Zhu, Pan.,Tan, Rong-Hui.,Zhao, Jin-Shun.,...&Bu, Shi-Zhong.(2018).Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy.JOURNAL OF FUNCTIONAL FOODS,45,427-434.
MLA Zhang, Yuan-Ming,et al."Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy".JOURNAL OF FUNCTIONAL FOODS 45(2018):427-434.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Yuan-Ming]'s Articles
[Zhang, Xiao-Hong]'s Articles
[Zhu, Pan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Yuan-Ming]'s Articles
[Zhang, Xiao-Hong]'s Articles
[Zhu, Pan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Yuan-Ming]'s Articles
[Zhang, Xiao-Hong]'s Articles
[Zhu, Pan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.