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Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract
Fong W.-F.; Wang C.; Zhu G.-Y.; Leung C.-H.; Yang M.-S.; Cheung H.-Y.
2007-02-19
Source PublicationPhytomedicine
ISSN09447113
Volume14Issue:2-3Pages:160-165
Abstract

Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp. © 2006 Elsevier GmbH. All rights reserved.

KeywordHepg2-dr Cells K562-dr Cells Multidrug Resistance P-glycoprotein Rhizoma Alismatis
DOI10.1016/j.phymed.2006.03.004
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000244975200012
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Cited Times [WOS]:39   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationCity University of Hong Kong
Recommended Citation
GB/T 7714
Fong W.-F.,Wang C.,Zhu G.-Y.,et al. Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract[J]. Phytomedicine,2007,14(2-3):160-165.
APA Fong W.-F.,Wang C.,Zhu G.-Y.,Leung C.-H.,Yang M.-S.,&Cheung H.-Y..(2007).Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract.Phytomedicine,14(2-3),160-165.
MLA Fong W.-F.,et al."Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract".Phytomedicine 14.2-3(2007):160-165.
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