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Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan
Leung C.-H.1; Lam W.2; Ma D.-L.1; Gullen E.A.2; Cheng Y.-C.2
2009-12-01
Source PublicationEuropean Journal of Immunology
ISSN00142980 15214141
Volume39Issue:12Pages:3529-3537
AbstractThe interaction between digestive tract microbiological flora and food has an important influence on human health. Butyrate is produced during the fermentation of dietary fibres by intestinal bacteria and plays an important role in the regulation of mucosal immunity. In this report, we studied the impact of butyrate on the defence mechanism against the bacterial membrane component peptidoglycan (PGN). Butyrate was found to enhance PGN-mediated IL-8 and GRO-α production. The expression of these chemokines required the activation of NF-κB and was dependent on the concentrations of butyrate and PGN. Butyrate was found to up-regulate nucleotide-binding and oligomerisation domain (NOD) 2, but not NOD1 or TLR2. NOD2 up-regulation was mediated by an increase in histone acetylation in the Nod2 promoter region, leading to enhanced PGN-induced IL-8 and GRO-α secretion. Knockdown of NOD2 and TLR2 by siRNA significantly reduced PGN-mediated chemokine production, suggesting that both NOD2 and TLR2 are required for maximal response. Our findings provide a better understanding of the mechanism by which butyrate regulates mucosal immunity for normal intestinal function. Based on the results of this study, we infer that dietary fibres can impact inflammatory bowel diseases. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
KeywordButyrate Intestinal immunity Nucleotide-binding and oligomerization domains (NOD) Peptidoglycan TLR
DOI10.1002/eji.200939454
URLView the original
Language英語
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
2.Yale University
Recommended Citation
GB/T 7714
Leung C.-H.,Lam W.,Ma D.-L.,et al. Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan[J]. European Journal of Immunology,2009,39(12):3529-3537.
APA Leung C.-H.,Lam W.,Ma D.-L.,Gullen E.A.,&Cheng Y.-C..(2009).Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan.European Journal of Immunology,39(12),3529-3537.
MLA Leung C.-H.,et al."Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan".European Journal of Immunology 39.12(2009):3529-3537.
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