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Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons
Liu J.1; Leung C.-H.1; Chow A.L.-F.1; Sun R.W.-Y.1; Yan S.-C.2; Che C.-M.1
2011-01-14
Source PublicationChemical Communications
ISSN13597345
Volume47Issue:2Pages:719-721
AbstractA platinum(ii)-based major groove binder [Pt(ĈN) (C≡NR)] (HCN = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16. © The Royal Society of Chemistry 2011.
DOI10.1039/c0cc03641b
URLView the original
Language英語
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被引频次[WOS]:38   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题University of Macau
Affiliation1.Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
2.Hong Kong Polytechnic University
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Liu J.,Leung C.-H.,Chow A.L.-F.,et al. Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons[J]. Chemical Communications,2011,47(2):719-721.
APA Liu J.,Leung C.-H.,Chow A.L.-F.,Sun R.W.-Y.,Yan S.-C.,&Che C.-M..(2011).Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons.Chemical Communications,47(2),719-721.
MLA Liu J.,et al."Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons".Chemical Communications 47.2(2011):719-721.
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