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DNA-Binding Small Molecules as Inhibitors of Transcription Factors
Leung C.-H.1; Chan D.S.-H.2; Ma V.P.-Y.2; Ma D.-L.2
2013-07-01
Source PublicationMedicinal Research Reviews
ISSN01986325 10981128
Volume33Issue:4Pages:823-846
AbstractAccumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA-binding small molecules to selectively inhibit transcription factor-DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA-binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed. © 2012 Wiley Periodicals, Inc.
KeywordGroove binding Inhibitor Intercalation Small molecule Transcription factor
DOI10.1002/med.21266
URLView the original
Language英語
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.University of Macau
2.Hong Kong Baptist University
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Leung C.-H.,Chan D.S.-H.,Ma V.P.-Y.,et al. DNA-Binding Small Molecules as Inhibitors of Transcription Factors[J]. Medicinal Research Reviews,2013,33(4):823-846.
APA Leung C.-H.,Chan D.S.-H.,Ma V.P.-Y.,&Ma D.-L..(2013).DNA-Binding Small Molecules as Inhibitors of Transcription Factors.Medicinal Research Reviews,33(4),823-846.
MLA Leung C.-H.,et al."DNA-Binding Small Molecules as Inhibitors of Transcription Factors".Medicinal Research Reviews 33.4(2013):823-846.
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