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Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex
Lu L.1; He H.-Z.1; Zhong H.-J.2; Liu L.-J.2; Chan D.S.-H.1; Leung C.-H.2; Ma D.-L.1
2014-10-01
Source PublicationSensors and Actuators, B: Chemical
ISSN09254005
Volume201Pages:177-184
AbstractA novel cyclometalated iridium(III) complex has been developed as a luminescent probe for human serum albumin (HSA) detection in aqueous solution. In this system, the initial luminescence of the iridium(III) complex in the absence of human serum albumin is weak. However, the addition of HSA could greatly enhance the luminescence intensity of iridium(III) complex. The assay could detect down to 0.05 μM of HSA, and also exhibited good selectivity for HSA over bovine serum albumin and other biomolecules such as ATP, β-amyloid, peroxidase, thrombin, lysozyme, trypsin, hemoglobin, and the various nucleic acids. Furthermore, the application of the assay for the detection of HSA in diluted urine samples and for monitoring the conformational changes of HSA induced by exogenous protein unfolding agents was also demonstrated. © 2014 Elsevier B.V.
KeywordHuman serum albumin Iridium(III) complex Luminescence Probe
DOI10.1016/j.snb.2014.04.100
URLView the original
Language英語
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong Baptist University
2.University of Macau
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Lu L.,He H.-Z.,Zhong H.-J.,et al. Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex[J]. Sensors and Actuators, B: Chemical,2014,201:177-184.
APA Lu L..,He H.-Z..,Zhong H.-J..,Liu L.-J..,Chan D.S.-H..,...&Ma D.-L..(2014).Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex.Sensors and Actuators, B: Chemical,201,177-184.
MLA Lu L.,et al."Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex".Sensors and Actuators, B: Chemical 201(2014):177-184.
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