UM
A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation
Chan S.L.-F.2; Lu L.1; Lam T.L.2; Yan S.-C.2; Leung C.-H.3; Ma D.-L.1
2015
Source PublicationCurrent Alzheimer Research
ISSN18755828 15672050
Volume12Issue:5Pages:434-438
AbstractWe report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
Keyword2-acetylbenzo[b]thiophen-3-olate Alzheimer's disease Beta-amyloid Ruthenium(II) Tris(2-pyridylmethyl)amine
DOI10.2174/1567205012666150504150726
URLView the original
Language英語
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong Baptist University
2.Hong Kong Polytechnic University
3.University of Macau
Recommended Citation
GB/T 7714
Chan S.L.-F.,Lu L.,Lam T.L.,et al. A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation[J]. Current Alzheimer Research,2015,12(5):434-438.
APA Chan S.L.-F.,Lu L.,Lam T.L.,Yan S.-C.,Leung C.-H.,&Ma D.-L..(2015).A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation.Current Alzheimer Research,12(5),434-438.
MLA Chan S.L.-F.,et al."A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation".Current Alzheimer Research 12.5(2015):434-438.
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