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A metal-based tumour necrosis factor-alpha converting enzyme inhibitor
Leung C.-H.3; Liu L.-J.3; Lu L.1; He B.1; Kwong D.W.J.1; Wong C.-Y.2; Ma D.-L.1
2015-03-07
Source PublicationChemical Communications
ISSN1364548X 13597345
Volume51Issue:19Pages:3973-3976
Abstract

We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

DOI10.1039/c4cc09251a
URLView the original
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000350212600003
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist University
2.City University of Hong Kong
3.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Leung C.-H.,Liu L.-J.,Lu L.,et al. A metal-based tumour necrosis factor-alpha converting enzyme inhibitor[J]. Chemical Communications,2015,51(19):3973-3976.
APA Leung C.-H..,Liu L.-J..,Lu L..,He B..,Kwong D.W.J..,...&Ma D.-L..(2015).A metal-based tumour necrosis factor-alpha converting enzyme inhibitor.Chemical Communications,51(19),3973-3976.
MLA Leung C.-H.,et al."A metal-based tumour necrosis factor-alpha converting enzyme inhibitor".Chemical Communications 51.19(2015):3973-3976.
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