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Recent development of g-quadruplex probes for cellular imaging
Ma D.-L.1; Wang M.1; Lin S.1; Han Q.-B.1; Leung C.-H.2
2015-07-01
Source PublicationCurrent Topics in Medicinal Chemistry
ISSN18734294 15680266
Volume15Issue:19Pages:1957-1963
Abstract

The G-quadruplex structure is a non-canonical secondary DNA motif that is built from planar tetrads of guanine residues stabilized by Hoogsteen-type hydrogen bonding. Bioinformatics studies indicate that sequences rich in guanine that are able to form G-quadruplexes are widely distributed throughout the human genome, particularly in telomere and promoter regions of genes. G-quadruplex sequences found in the promoters of human oncogenes, such as k-ras, c-myc and bcl-2 have attracted particular attention as molecular targets for therapeutic intervention due to their potential capability to regulate gene expression at the transcriptional level. Moreover, the G-quadruplex structure has been associated with a number of human diseases arising from defective telomeric maintenance. Despite intensive research in this area, however, the actual function of G-quadruplexes in vivo has not yet been fully understood. Therefore, significant efforts have been devoted to the discovery of specific probes for visualizing and distinguishing G-quadruplex structures from other nucleic acid molecules likely to be found in biological environments. This review summarizes recent studies in the development of G-quadruplex probes over the past three years, with a particular emphasize on the detection and imaging of G-quadruplex structures within living cells. Furthermore, the detection and biological relevance of RNA G-quadruplexes is discussed.

KeywordCell Imaging Dna G-quadruplex Probe
DOI10.2174/1568026615666150515150106
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000357042600004
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa D.-L.
Affiliation1.Hong Kong Baptist University
2.University of Macau
Recommended Citation
GB/T 7714
Ma D.-L.,Wang M.,Lin S.,et al. Recent development of g-quadruplex probes for cellular imaging[J]. Current Topics in Medicinal Chemistry,2015,15(19):1957-1963.
APA Ma D.-L.,Wang M.,Lin S.,Han Q.-B.,&Leung C.-H..(2015).Recent development of g-quadruplex probes for cellular imaging.Current Topics in Medicinal Chemistry,15(19),1957-1963.
MLA Ma D.-L.,et al."Recent development of g-quadruplex probes for cellular imaging".Current Topics in Medicinal Chemistry 15.19(2015):1957-1963.
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