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A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture
Dik-Lung Ma1,2; Modi Wang1; Bingyong He1; Chao Yang3; Wanhe Wang1; Chung-Hang Leung3
2015-08-18
Source PublicationACS Applied Materials and Interfaces
ISSN19448252 19448244
Volume7Issue:34Pages:19060-19067
Abstract

In this study, a series of 10 in-house cyclometalated iridium(III) complexes bearing different auxiliary ligands were tested for their selectivity toward split G-quadruplex in order to construct a label-free switch-on cocaine detection platform employing a three-way junction architecture and a G-quadruplex motif as a signal output unit. Through two rounds of screening, we discovered that the iridium(III) complex 7 exhibited excellent selectivity toward the intermolecular G-quadruplex motif. A detection limit as low as 30 nM for cocaine can be achieved by this sensing approach with a linear relationship between luminescence intensity and cocaine concentration established from 30 to 300 nM. Furthermore, this sensing approach could detect cocaine in diluted oral fluid. We hope that our simple, signal-on, label-free oligonucleotide-based sensing method for cocaine using a three-way DNA junction architecture could act as a useful platform in bioanalytical research.

KeywordCocaine G-quadruplex Iridium(Iii) Complex Label-free Three-way Junction
DOI10.1021/acsami.5b05861
URLView the original
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000360868700022
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDik-Lung Ma; Chung-Hang Leung
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
2.Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Dik-Lung Ma,Modi Wang,Bingyong He,et al. A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture[J]. ACS Applied Materials and Interfaces,2015,7(34):19060-19067.
APA Dik-Lung Ma,Modi Wang,Bingyong He,Chao Yang,Wanhe Wang,&Chung-Hang Leung.(2015).A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture.ACS Applied Materials and Interfaces,7(34),19060-19067.
MLA Dik-Lung Ma,et al."A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture".ACS Applied Materials and Interfaces 7.34(2015):19060-19067.
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