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Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity
Lihua Lu2; Li-Juan Liu3; Wei-chieh Chao1; Hai-Jing Zhong3; Modi Wang2; Xiu-Ping Chen3; Jin-Jian Lu3; Ruei-nian Li1; Dik-Lung Ma2; Chung-Hang Leung3
2015-09-29
Source PublicationScientific Reports
ISSN20452322
Volume5
Abstract

Group 9 transition metal complexes have been widely explored as therapeutic agents due to their unique geometry, their propensity to undergo ligand exchanges with biomolecules and their diverse steric and electronic properties. These metal complexes can offer distinct modes of action in living organisms compared to carbon-based molecules. In this study, we investigated the antimicrobial and anti-proliferative abilities of a series of cyclometallated iridium(III) complexes. The iridium(III) complex 1 inhibited the growth of S. aureus with MIC and MBC values of 3.60 and 7.19 1/4M, respectively, indicating its potent bactericidal activity. Moreover, complex 1 also exhibited cytotoxicity against a number of cancer cell lines, with particular potency against ovarian, cervical and melanoma cells. This cyclometallated iridium(III) complex is the first example of a substitutionally-inert, Group 9 organometallic compound utilized as a direct and selective inhibitor of S. aureus.

DOI10.1038/srep14544
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000361880500001
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Lihua Lu,Li-Juan Liu,Wei-chieh Chao,et al. Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity[J]. Scientific Reports,2015,5.
APA Lihua Lu.,Li-Juan Liu.,Wei-chieh Chao.,Hai-Jing Zhong.,Modi Wang.,...&Chung-Hang Leung.(2015).Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity.Scientific Reports,5.
MLA Lihua Lu,et al."Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity".Scientific Reports 5(2015).
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