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Synergistic effects of linderanolide b combined with arbutin, PTU or kojic acid on tyrosinase inhibition
Hseu Y.-C.1,2; Cheng K.-C.3,4,5; Lin Y.-C.6; Chen C.-Y.7; Chou H.-Y.6; Ma D.-L.8; Leung C.-H.9; Wen Z.-H.10; Wang H.-M.D.6,11
2015-10-01
Source PublicationCurrent Pharmaceutical Biotechnology
ISSN18734316 13892010
Volume16Issue:12Pages:1120-1126
Abstract

Melanin uncontrollable accumulation is a serious social problem to not only women, but also men, and causes pigment over-expression disorders such as freckles, melasma or pigmented acne scars. The synergism is used widely in medication, and the effectiveness makes the drug applications more valuable. Within this experiment, three well-known compounds were chosen: kojic acid, 1-phenyl-2-thiourea (PTU) and arbutin, and they were combined individually with our substance linderanolide B, which is purified from Cinnamomum subavenium. Hence, deciphering the synergistic action of possible whitening agents was the goal of this study. The tyrosinase activity, melanin content, and the combination index (CI) values were observed in B16F10 cells, in addition, the consequences were detected by isobologram analysis. We discovered that certain melanin inhibitors showed synergistic properties when they were combined together to suppress tyrosinase activities. As a result, linderanolide B has a potential synergy on tyrosinase inhibition, and it can be used widely in cosmetic and medication industries.

KeywordInhibitor Melanin Synergism Tyrosinase
DOI10.2174/1389201016666150907112819
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS IDWOS:000361824800012
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang H.-M.D.
Affiliation1.China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan
2.‎ Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413, Taiwan
3.Chi Mei Med Ctr, Dept Internal Med, Tainan 710, Taiwan
4.Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm, Tainan 717, Taiwan
5.Natl Def Med Ctr, Dept Med, Taipei 114, Taiwan
6.Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, Kaohsiung 807, Taiwan
7.Fooyin Univ, Sch Med & Hlth Sci, Dept Nutr & Hlth Sci, Kaohsiung 831, Taiwan
8.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
9.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
10.Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
11.Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
Recommended Citation
GB/T 7714
Hseu Y.-C.,Cheng K.-C.,Lin Y.-C.,et al. Synergistic effects of linderanolide b combined with arbutin, PTU or kojic acid on tyrosinase inhibition[J]. Current Pharmaceutical Biotechnology,2015,16(12):1120-1126.
APA Hseu Y.-C..,Cheng K.-C..,Lin Y.-C..,Chen C.-Y..,Chou H.-Y..,...&Wang H.-M.D..(2015).Synergistic effects of linderanolide b combined with arbutin, PTU or kojic acid on tyrosinase inhibition.Current Pharmaceutical Biotechnology,16(12),1120-1126.
MLA Hseu Y.-C.,et al."Synergistic effects of linderanolide b combined with arbutin, PTU or kojic acid on tyrosinase inhibition".Current Pharmaceutical Biotechnology 16.12(2015):1120-1126.
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