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A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α
Lu L.1; Wang M.1; Mao Z.1; Kang T.-S.2; Chen X.-P.2; Lu J.-J.2; Leung C.-H.2; Ma D.-L.1
2016-03-02
Source PublicationScientific Reports
ISSN20452322
Volume6
Abstract

A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.

DOI10.1038/srep22458
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000371152600001
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist University
2.University of Macau
Recommended Citation
GB/T 7714
Lu L.,Wang M.,Mao Z.,et al. A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α[J]. Scientific Reports,2016,6.
APA Lu L..,Wang M..,Mao Z..,Kang T.-S..,Chen X.-P..,...&Ma D.-L..(2016).A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α.Scientific Reports,6.
MLA Lu L.,et al."A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α".Scientific Reports 6(2016).
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