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An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells
Liu J.-B.3; Liu L.-J.2; Dong Z.-Z.1; Yang G.-J.2; Leung C.-H.2; Ma D.-L.1
2016-11-04
Source PublicationScientific Reports
ISSN20452322
Volume6
AbstractA long-lived aldol reaction-based iridium(III) chemosensor [Ir(ppy) 2 (5-CHOphen)]PF 6 (1, where ppy = 2-phenylpyridine and 5-CHOphen = 1,10-phenanthroline-5-carbaldehyde) for proline detection has been synthesized. The iridium(III) complex 1, incorporating an aldehyde group in N^N donor ligand, can take part in aldol reaction with acetone mediated by proline. The transformation of the sp 2-hybridized carbonyl group into a sp 3-hybridized alcohol group influences the metal-to-ligand charge-transfer (MLCT) state of the iridium(III) complex, resulting in a change in luminescence in response to proline. The interaction of the iridium(III) complex 1 with proline was investigated by 1 H NMR, HRMS and emission titration experiments. Upon the addition of proline to a solution of iridium(III) complex 1, a maximum 8-fold luminescence enhancement was observed. The luminescence signal of iridium(III) complex 1 could be recognized in strongly fluorescent media using time-resolved emission spectroscopy (TRES). The detection of proline in living cells was also demonstrated.
DOI10.1038/srep36509
URLView the original
Language英語
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong Baptist University
2.University of Macau
3.Jiangxi University of Science and Technology
Recommended Citation
GB/T 7714
Liu J.-B.,Liu L.-J.,Dong Z.-Z.,et al. An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells[J]. Scientific Reports,2016,6.
APA Liu J.-B.,Liu L.-J.,Dong Z.-Z.,Yang G.-J.,Leung C.-H.,&Ma D.-L..(2016).An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells.Scientific Reports,6.
MLA Liu J.-B.,et al."An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells".Scientific Reports 6(2016).
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