UM
Antagonizing STAT5B dimerization with an osmium complex
Liu L.-J.2; Wang W.1; Kang T.-S.2; Liang J.-X.2; Liu C.1; Kwong D.W.J.1; Wong V.K.W.3; Ma D.-L.1; Leung C.-H.2
2016-11-17
Source PublicationScientific Reports
ISSN20452322
Volume6
AbstractTargeting STAT5 is an appealing therapeutic strategy for the treatment of hematologic malignancies and inflammation. Here, we present the novel osmium(II) complex 1 as the first metal-based inhibitor of STAT5B dimerization. Complex 1 exhibited superior inhibitory activity against STAT5B DNA binding compared to STAT5A DNA binding. Moreover, 1 repressed STAT5B transcription and blocked STAT5B dimerization via binding to the STAT5B protein, thereby inhibiting STAT5B translocation to the nucleus. Furthermore, 1 was able to selectively inhibit STAT5B phosphorylation without affecting the expression level of STAT5B.
DOI10.1038/srep36044
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong Baptist University
2.University of Macau
3.Macau University of Science and Technology
First Author AffilicationUniversity of Macau
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GB/T 7714
Liu L.-J.,Wang W.,Kang T.-S.,et al. Antagonizing STAT5B dimerization with an osmium complex[J]. Scientific Reports,2016,6.
APA Liu L.-J..,Wang W..,Kang T.-S..,Liang J.-X..,Liu C..,...&Leung C.-H..(2016).Antagonizing STAT5B dimerization with an osmium complex.Scientific Reports,6.
MLA Liu L.-J.,et al."Antagonizing STAT5B dimerization with an osmium complex".Scientific Reports 6(2016).
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