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Carrageenan activates monocytes via type-specific binding with interleukin-8: An implication for design of immuno-active biomaterials
Chan W.-I.4; Zhang G.4; Li X.1; Leung C.-H.4; Ma D.-L.2; Dong L.3; Wang C.4
2017-03-01
Source PublicationBiomaterials Science
ISSN20474849 20474830
Volume5Issue:3Pages:403-407
Abstract

Polymers that can activate the immune system may become useful biomaterials tools, given that the mechanisms underlying their actions are well understood. Herein, we report a novel type of interaction between polymers and immune cells-in studying the influence of the three major types of carrageenan (CGN) polysaccharides on monocyte behaviour in vitro, we found only the λ-type induced monocyte adhesion and this action requires the presence of an adequate amount of serum. Further analyses indicated λ-CGN bound interleukin-8 (IL-8) in the serum and activated the cultured monocytes through an IL-8-dependent pathway. This is the first demonstration that a polymer, with a renowned immunostimulatory effect, activates the immune system via binding and harnessing the function of a specific cytokine in the microenvironment. This is a new mechanism underlying polymer-immunity interactions that may shed light on future design and application of biomaterials tools targeting the immune system for a wide variety of therapeutic applications.

DOI10.1039/c6bm00799f
URLView the original
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000395886300004
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Thermo Fisher Scientific
2.Hong Kong Baptist University
3.Nanjing University
4.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chan W.-I.,Zhang G.,Li X.,et al. Carrageenan activates monocytes via type-specific binding with interleukin-8: An implication for design of immuno-active biomaterials[J]. Biomaterials Science,2017,5(3):403-407.
APA Chan W.-I..,Zhang G..,Li X..,Leung C.-H..,Ma D.-L..,...&Wang C..(2017).Carrageenan activates monocytes via type-specific binding with interleukin-8: An implication for design of immuno-active biomaterials.Biomaterials Science,5(3),403-407.
MLA Chan W.-I.,et al."Carrageenan activates monocytes via type-specific binding with interleukin-8: An implication for design of immuno-active biomaterials".Biomaterials Science 5.3(2017):403-407.
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