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Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity
Ng S.-W.1; Chung L.-H.1; Yeung C.-F.1; Lo H.-S.1; Shek H.-L.1; Kang T.-S.3; Leung C.-H.3; Ma D.-L.2; Wong C.-Y.1
2018-02-06
Source PublicationChemistry - A European Journal
ISSN15213765 09476539
Volume24Issue:8Pages:1779-1783
Abstract

The two families of Ru-chromene and -chromone complexes isolated in this work represent the first examples of metalated chromene and chromone complexes synthesized through transition-metal-mediated cyclization of phenol-tethered ynone. These unprecedented metalated heterocyclic compounds exhibit remarkable features, such as pH-switchable metal–carbon bonding interactions, photo-triggerable release of organic chromone upon visible-light irradiation, and superior antioxidative property to their organic analogue (1,4-benzopyrone). These findings not only offer mechanistic insights into metal-induced activation of functionalized alkynes, but also add a new dimension to rational design of antioxidants and photo-responsive drug delivery systems.

KeywordAlkynes Antioxidants Chromones Photochemistry Ruthenium
DOI10.1002/chem.201705450
URLView the original
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000424226000004
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.City University of Hong Kong
2.Hong Kong Baptist University
3.University of Macau
Recommended Citation
GB/T 7714
Ng S.-W.,Chung L.-H.,Yeung C.-F.,et al. Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity[J]. Chemistry - A European Journal,2018,24(8):1779-1783.
APA Ng S.-W..,Chung L.-H..,Yeung C.-F..,Lo H.-S..,Shek H.-L..,...&Wong C.-Y..(2018).Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity.Chemistry - A European Journal,24(8),1779-1783.
MLA Ng S.-W.,et al."Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity".Chemistry - A European Journal 24.8(2018):1779-1783.
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