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UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats
Zhang, Mengliu1,2,3; Wang, Yang4; Zhang, Qian1; Wang, Changsheng1; Zhang, Dawei5; Wan, Jian-Bo4; Yan, Chunyan1
2018-06
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume112Pages:433-441
Abstract

Osteoporosis is a frequent disease among the elderly especially in postmenopausal women. Achyranthes bidentata is a traditional Chinese medicine used to strengthen bones. Here, A. bidentata polysaccharides (ABPs) were confirmed to have anti-osteoporosis effects. This study discovered biomarkers by comparing normal and osteoporosis rats and evaluated the effects of ABPs on osteoporosis based on the UPLC/Q-TOF-MS-based metabolomics analysis. We could then predict the underlying mechanisms from the perspective of metabolomics. Osteoporotic rats were treated with ABPs, and serum was then sampled for metabolic analysis. Glutarylcamitine, lysoPC (18:1) and 9-cis-retinoic add were identified as biomarkers. The ABPs could significantly increase these biomarkers, and this indicated that ABPs curing osteoporosis regulated lipid metabolism. The UPLC/Q-TOF-MS-based metabolomics analysis offered a potential strategy to evaluate the anti-osteoporosis effects of ABPs and to explain the relative mechanisms. Furthermore, the ABPs have good potential for treating osteoporosis. (C) 2018 Elsevier B.V. All rights reserved.

KeywordAchyranthes Bidentata Polysaccharides Metabolomics
DOI10.1016/j.ijbiomac.2018.01.204
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000430522400051
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
2.Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, PR China
3.Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, PR China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, PR China
5.School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, PR China
Recommended Citation
GB/T 7714
Zhang, Mengliu,Wang, Yang,Zhang, Qian,et al. UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,112:433-441.
APA Zhang, Mengliu.,Wang, Yang.,Zhang, Qian.,Wang, Changsheng.,Zhang, Dawei.,...&Yan, Chunyan.(2018).UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,112,433-441.
MLA Zhang, Mengliu,et al."UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 112(2018):433-441.
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