Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer | |
Zhang Z.1; Yu C.1; Zhang C.-F.1; Wu X.-H.1; Wen X.-D.1; Anderson S.1; Yuan C.-S.1; Du W.1; Huang W.-H.2; Li S.-P.3![]() | |
2014-07-18 | |
Source Publication | Nutrients
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ISSN | 20726643 |
Volume | 6Issue:7Pages:2668-2680 |
Abstract | Oplopanax horridus is a North American botanical that has received limited investigations. We previously isolated over a dozen of the constituents from O. horridus, and among them oplopantriol A (OPT A) is a novel compound. In this study, we firstly evaluated the in vivo chemoprevention activities of OPT A using the xenograft colon cancer mouse model. Our data showed that this compound significantly suppressed tumor growth with dose-related effects (p < 0.01). Next, we characterized the compound's growth inhibitory effects in human colorectal cancer cell lines HCT-116 and SW-480. With OPT A treatment, these malignant cells were significantly inhibited in both a concentration- and time-dependent manner (both p < 0.01). The IC50 was approximately 5 μM for HCT-116 and 7 μM for SW-480 cells. OPT A significantly induced apoptosis and arrested the cell cycle at the G2/M phase. From further mechanism explorations, our data showed that OPT A significantly upregulated the expression of a cluster of genes, especially the tumor necrosis factor receptor family and caspase family, suggesting that the tumor necrosis factor-related apoptotic pathway plays a key role in OPT A induced apoptosis. © 2014 by the authors; licensee MDPI, Basel, Switzerland. |
Keyword | Apoptosis Cell Cycle Chemoprevention Colorectal Cancer Death Receptor Signaling Pathway Hct-116 Oplopanax Horridus Oplopantriol a Opt a Sw-480 Tumor Necrosis Factors |
DOI | 10.3390/nu6072668 |
URL | View the original |
Indexed By | SCI |
WOS Research Area | Nutrition & Dietetics |
WOS Subject | Nutrition & Dietetics |
WOS ID | WOS:000339989400012 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Affiliation | 1.University of Chicago Pritzker School of Medicine 2.Central South University China 3.University of Macau |
Recommended Citation GB/T 7714 | Zhang Z.,Yu C.,Zhang C.-F.,et al. Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer[J]. Nutrients,2014,6(7):2668-2680. |
APA | Zhang Z..,Yu C..,Zhang C.-F..,Wu X.-H..,Wen X.-D..,...&Wang C.-Z..(2014).Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer.Nutrients,6(7),2668-2680. |
MLA | Zhang Z.,et al."Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer".Nutrients 6.7(2014):2668-2680. |
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