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Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer
Zhang Z.1; Yu C.1; Zhang C.-F.1; Wu X.-H.1; Wen X.-D.1; Anderson S.1; Yuan C.-S.1; Du W.1; Huang W.-H.2; Li S.-P.3; Wang C.-Z.1
2014-07-18
Source PublicationNutrients
ISSN20726643
Volume6Issue:7Pages:2668-2680
Abstract

Oplopanax horridus is a North American botanical that has received limited investigations. We previously isolated over a dozen of the constituents from O. horridus, and among them oplopantriol A (OPT A) is a novel compound. In this study, we firstly evaluated the in vivo chemoprevention activities of OPT A using the xenograft colon cancer mouse model. Our data showed that this compound significantly suppressed tumor growth with dose-related effects (p < 0.01). Next, we characterized the compound's growth inhibitory effects in human colorectal cancer cell lines HCT-116 and SW-480. With OPT A treatment, these malignant cells were significantly inhibited in both a concentration- and time-dependent manner (both p < 0.01). The IC50 was approximately 5 μM for HCT-116 and 7 μM for SW-480 cells. OPT A significantly induced apoptosis and arrested the cell cycle at the G2/M phase. From further mechanism explorations, our data showed that OPT A significantly upregulated the expression of a cluster of genes, especially the tumor necrosis factor receptor family and caspase family, suggesting that the tumor necrosis factor-related apoptotic pathway plays a key role in OPT A induced apoptosis. © 2014 by the authors; licensee MDPI, Basel, Switzerland.

KeywordApoptosis Cell Cycle Chemoprevention Colorectal Cancer Death Receptor Signaling Pathway Hct-116 Oplopanax Horridus Oplopantriol a Opt a Sw-480 Tumor Necrosis Factors
DOI10.3390/nu6072668
URLView the original
Indexed BySCI
WOS Research AreaNutrition & Dietetics
WOS SubjectNutrition & Dietetics
WOS IDWOS:000339989400012
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.University of Chicago Pritzker School of Medicine
2.Central South University China
3.University of Macau
Recommended Citation
GB/T 7714
Zhang Z.,Yu C.,Zhang C.-F.,et al. Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer[J]. Nutrients,2014,6(7):2668-2680.
APA Zhang Z..,Yu C..,Zhang C.-F..,Wu X.-H..,Wen X.-D..,...&Wang C.-Z..(2014).Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer.Nutrients,6(7),2668-2680.
MLA Zhang Z.,et al."Chemopreventive effects of oplopantriol A, a novel compound isolated from oplopanax horridus, on colorectal cancer".Nutrients 6.7(2014):2668-2680.
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