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Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells
Il Y.C.1; Hui F.D.2; Zhang X.1; Hassanein N.M.A.1; Howard O.M.Z.1; Oppenheim J.J.1; Chen X.2
2004-11-01
Source PublicationCellular Immunology
ISSN00088749
Volume232Issue:1-2Pages:57-63
Abstract

Since we have previously shown that dexamethasone (Dex) enhances the proportion of murine Treg cells, we tested the effect of IL-7, a promoter of T cell survival, together with Dex on human CD4CD25 Treg cells in an in vitro setting. The results showed that IL-7 in concert with Dex markedly augmented the generation of CD4CD25 T cells. To discern the origin of the induced CD4CD25 T cells, MACS-purified CD4CD25, and CD4CD25 cells were cultured in the presence of Dex and/or IL-7 for 4 days. Although two thirds of CD4CD25 T cells became CD4 CD25 T cells, they had no suppressive activity. In contrast, the original CD4CD25 T cells maintained suppressive activity after Dex/IL-7 treatment, however, there was not a significant expansion in their cell number. Dex and IL-7 did not induce additional Treg cells, but additively induced the expression of the activation marker CD25 by CD4CD25 T cells. This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases. © 2005 Elsevier Inc. All rights reserved.

Keywordcd4+cd25+ Regulatory t Lymphocytes Dexamethasone Interleukin-7 Suppression/anergy
DOI10.1016/j.cellimm.2005.01.011
URLView the original
Indexed BySCI
WOS Research AreaCell Biology ; Immunology
WOS SubjectCell Biology ; Immunology
WOS IDWOS:000229764300007
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.National Cancer Institute at Frederick
2.SAIC-Frederick
3.National Organization for Drug Control and Research Egypt
4.Hanyang University
Recommended Citation
GB/T 7714
Il Y.C.,Hui F.D.,Zhang X.,et al. Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells[J]. Cellular Immunology,2004,232(1-2):57-63.
APA Il Y.C..,Hui F.D..,Zhang X..,Hassanein N.M.A..,Howard O.M.Z..,...&Chen X..(2004).Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells.Cellular Immunology,232(1-2),57-63.
MLA Il Y.C.,et al."Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells".Cellular Immunology 232.1-2(2004):57-63.
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