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Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
Krakauer T.1; Chen X.3; Howard O.M.Z.2; Young H.A.4
2005
Source PublicationImmunopharmacology and Immunotoxicology
ISSN15322513 08923973
Volume27Issue:1Pages:53-66
Abstract

Proinflammatory cytokines mediate the toxic effects of superantigenic staphylococcal exotoxins (SE) and bacterial lipopolysaccharide (LPS). Triptolide, an oxygenated diterpene derived from a traditional Chinese medicinal herb, Tripterygium wilfordii, inhibited SE-stimulated T-cell proliferation (by 98%) and expression of interleukin 1β, interleukin 6, tumor necrosis factor, gamma interferon, monocyte chemotactic protein 1, macrophage inflammatory protein (MIP)-1α, and MIP-1β by human peripheral blood mononuclear cells (PBMC). It also blocked the production of these cytokines and chemokines by LPS-stimulated PBMC in a dose-dependent manner. These results suggest that triptolide has potent immunosuppressive effects even counteracting the effects of superantigens and LPS. It also may be therapeutically useful for mitigating the pathogenic effects of these microbial products by downregulating the signaling pathways activated by both bacterial exotoxins and endotoxins. Copyright © 2005 Taylor &, Francis Inc.

KeywordCytokine Immunosuppression Lps Seb Triptolide Tsst-1
DOI10.1081/IPH-51294
URLView the original
Indexed BySCI
WOS Research AreaImmunology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectImmunology ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000227939800004
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被引频次[WOS]:34   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.United States Army
2.Laboratory of Molecular Immunoregulation
3.SAIC-Frederick
4.National Cancer Institute at Frederick
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Krakauer T.,Chen X.,Howard O.M.Z.,et al. Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines[J]. Immunopharmacology and Immunotoxicology,2005,27(1):53-66.
APA Krakauer T.,Chen X.,Howard O.M.Z.,&Young H.A..(2005).Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.Immunopharmacology and Immunotoxicology,27(1),53-66.
MLA Krakauer T.,et al."Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines".Immunopharmacology and Immunotoxicology 27.1(2005):53-66.
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