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Cutting Edge: Expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: Applicability to tumor-infiltrating T regulatory cells
Chen X.1; Subleski J.J.2; Kopf H.2; Zack Howard O.M.2; Mannel D.N.3; Oppenheim J.J.2
2008
Source PublicationJournal of Immunology
ISSN15506606 00221767
Volume180Issue:10Pages:6467-6471
AbstractTNFR2 is predominantly expressed by a subset of human and mouse CD4 CD25FoxP3 T regulatory cells (Tregs). In this study, we characterized the phenotype and function of TNFR2 Tregs in peripheral lymphoid tissues of normal and tumor-bearing C57BL/6 mice. We found that TNFR2 was expressed on 30-40% of the Tregs of the peripheral activated/memory subset that were most highly suppressive. In contrast, TNFR2 Tregs exhibited the phenotype of naive cells and only had minimal suppressive activity. Although not typically considered to be Tregs, CD4 CD25TNFR2 cells nevertheless possessed moderate suppressive activity. Strikingly, the suppressive activity of TNFR2 Tregs was considerably more potent than that of reportedly highly suppressive CD103 Tregs. In the Lewis lung carcinoma model, more highly suppressive TNFR2 Tregs accumulated intratumorally than in the periphery. Thus, TNFR2 identifies a unique subset of mouse Tregs with an activated/memory phenotype and maximal suppressive activity that may account for tumor-infiltrating lymphocyte-mediated immune evasion by tumors. Copyright © 2008 by The American Association of Immunologists, Inc.
DOI10.4049/jimmunol.180.10.6467
URLView the original
Language英語
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Cited Times [WOS]:143   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.SAIC-Frederick
2.National Cancer Institute at Frederick
3.Universitat Regensburg
Recommended Citation
GB/T 7714
Chen X.,Subleski J.J.,Kopf H.,et al. Cutting Edge: Expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: Applicability to tumor-infiltrating T regulatory cells[J]. Journal of Immunology,2008,180(10):6467-6471.
APA Chen X.,Subleski J.J.,Kopf H.,Zack Howard O.M.,Mannel D.N.,&Oppenheim J.J..(2008).Cutting Edge: Expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: Applicability to tumor-infiltrating T regulatory cells.Journal of Immunology,180(10),6467-6471.
MLA Chen X.,et al."Cutting Edge: Expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: Applicability to tumor-infiltrating T regulatory cells".Journal of Immunology 180.10(2008):6467-6471.
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