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Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients
Yan F.1; Du R.1; Wei F.1; Zhao H.1; Yu J.1; Wang C.3; Zhan Z.3; Ding T.1; Ren X.1; Chen X.4; Li H.1
2015-11-01
Source PublicationCancer Immunology, Immunotherapy
ISSN14320851 03407004
Volume64Issue:11Pages:1475-1485
Abstract

CD4FoxP3 regulatory T cells (Tregs) represent a major cellular mediator of cancer immune evasion. The expression of tumor necrosis factor receptor type II (TNFR2) on Tregs is reported to identify the maximally suppressive Treg population in both mice and human. We therefore investigated the phenotype and function of TNFR2 Tregs present in the peripheral blood (PB) of 43 lung cancer patients. Further, the association of TNFR2 expression on Tregs with clinicopathological factors was analyzed. The results showed that in the PB of lung cancer patients, Tregs expressed markedly higher levels of TNFR2 than conventional T cells (Tconvs). Expression of TNFR2 appeared to correlate better than CD25 and CD127 with FoxP3 expression. PB TNFR2 Tregs in lung cancer patients were more proliferative and expressed higher levels of the immunosuppressive molecule CTLA-4, and consequently more potently suppressed IFNγ production by cocultured CD8 CTLs. More importantly, higher TNFR2 expression levels on Tregs were associated with lymphatic invasion, distant metastasis and more advanced clinical stage of lung cancer patients. Therefore, our study suggests that TNFR2 Tregs play a role in promoting tumor progressive metastasis and expression of TNFR2 by PB Tregs may prove to be a useful prognostic marker in lung cancer patients.

Keywordcd4+foxp3+ Regulatory t Cells Clinical Pathology Immunosuppression Lung Cancer Tumor Necrosis Factor Receptor Type Ii (Tnfr2)
DOI10.1007/s00262-015-1751-z
URLView the original
Indexed BySCI
WOS Research AreaOncology ; Immunology
WOS SubjectOncology ; Immunology
WOS IDWOS:000363247400011
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Tianjin Medical University
2.Key Laboratory of Cancer Immunology and Biotherapy
3.National Clinical Research Center for Cancer
4.University of Macau
Recommended Citation
GB/T 7714
Yan F.,Du R.,Wei F.,et al. Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients[J]. Cancer Immunology, Immunotherapy,2015,64(11):1475-1485.
APA Yan F..,Du R..,Wei F..,Zhao H..,Yu J..,...&Li H..(2015).Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients.Cancer Immunology, Immunotherapy,64(11),1475-1485.
MLA Yan F.,et al."Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients".Cancer Immunology, Immunotherapy 64.11(2015):1475-1485.
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