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TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis
Chen X.2; Nie Y.3; Xiao H.3; Bian Z.1; Scarzello A.J.3; Song N.-Y.3; Anna T.L.3; Yang D.3; Oppenheim J.J.3
2016-09-07
Source PublicationScientific Reports
ISSN20452322
Volume6
Abstract

There is now compelling evidence that TNFR2 is constitutively expressed on CD4 + Foxp3 + regulatory T cells (Tregs) and TNF-TNFR2 interaction is critical for the activation, expansion and functional stability of Tregs. However, we showed that the expression of TNFR2 was also up-regulated on CD4 + Foxp3 effector T cells (Teffs) upon TCR stimulation. In order to define the role of TNFR2 in the pathogenic CD4 T cells, we compared the effect of transferred naïve CD4 cells from WT mice and TNFR2 -/- mice into Rag 1 -/- recipients. Transfer of TNFR2-deficient Teff cells failed to induce full-fledged colitis, unlike WT Teffs. This was due to defective proliferative expansion of TNFR2-deficient Teff cells in the lymphopenic mice, as well as their reduced capacity to express proinflammatory Th1 cytokine on a per cell basis. In vitro, the proliferative response of TNFR2 deficient naïve CD4 cells to anti-CD3 stimulation was markedly decreased as compared with that of WT naïve CD4 cells. The hypoproliferative response of TNFR2-deficient Teff cells to TCR stimulation was associated with an increased ratio of p100/p52, providing a mechanistic basis for our findings. Therefore, this study clearly indicates that TNFR2 is important for the proliferative expansion of pathogenic Teff cells.

DOI10.1038/srep32834
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000382611800001
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist University
2.University of Macau
3.National Cancer Institute at Frederick
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chen X.,Nie Y.,Xiao H.,et al. TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis[J]. Scientific Reports,2016,6.
APA Chen X..,Nie Y..,Xiao H..,Bian Z..,Scarzello A.J..,...&Oppenheim J.J..(2016).TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.Scientific Reports,6.
MLA Chen X.,et al."TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis".Scientific Reports 6(2016).
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