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Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery
Seto S.W.1; Lam H.Y.1; Lau W.S.1; Au A.L.S.1; Lam T.Y.1; Chim S.S.C.1; Ngai S.M.1; Chan S.W.2; Leung T.Y.1; Yeung J.H.K.1; Kong S.K.1; Leung G.P.H.3; Lee S.M.Y.4; Kwan Y.W.1
2009-03-01
Source PublicationEuropean Journal of Pharmacology
ISSN00142999
Volume605Issue:1-3Pages:129-137
Abstract

We investigated the role(s) of monoamine oxidases (MAOs) on the altered 5-hydroxytryptamine (5-HT, serotonin)-induced tension development of the isolated umbilical artery of preeclamptic pregnancy of Chinese women. An enhanced 5-HT-induced tension development of the umbilical artery of preeclamptic pregnancy was observed when compared with that of normal pregnancy. The enhanced component of 5-HT-induced tension development was eradicated by clorgyline (a MAO-A inhibitor). Blockade of eNOS (endothelial isoform nitric oxide synthase) (N-nitro-l-arginine methyl ester), 5-HT transporter (citalopram), 5-HT receptor subtypes (5HT, SB 204741; 5-HT, RS 102221; 5-HT, SB 269970), and endothelium denudation of the umbilical artery of normal pregnancy mimicked the enhanced 5-HT-induced tension development as observed in the preeclamptic tissues. In contrast, no apparent changes in 5-HT-induced tension development of the umbilical artery of preeclamptic pregnancy were observed with the same pharmacological manipulations. A decreased protein expression levels of MAO-A and eNOS (no iNOS and MAO-B expression was detected) and no change in caveolin-1 and 5-HT transporter expression were demonstrated in the umbilical artery (endothelium intact) lysate of preeclamptic pregnancy, compared to that of the umbilical artery of normal pregnancy. Thus, in the umbilical artery of preeclamptic pregnancy, a decrease of MAO-A and eNOS protein expression levels are probably associated with, or responsible for, the exaggerated 5-HT-induced tension development. © 2009 Elsevier B.V. All rights reserved.

Keyword5-hydroxytryptamine Monoamine Oxidase Preeclampsia Umbilical Artery
DOI10.1016/j.ejphar.2008.12.054
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000264407300021
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chinese University of Hong Kong
2.Hong Kong Polytechnic University
3.The University of Hong Kong
4.University of Macau
Recommended Citation
GB/T 7714
Seto S.W.,Lam H.Y.,Lau W.S.,et al. Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery[J]. European Journal of Pharmacology,2009,605(1-3):129-137.
APA Seto S.W..,Lam H.Y..,Lau W.S..,Au A.L.S..,Lam T.Y..,...&Kwan Y.W..(2009).Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery.European Journal of Pharmacology,605(1-3),129-137.
MLA Seto S.W.,et al."Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery".European Journal of Pharmacology 605.1-3(2009):129-137.
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