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Folic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice
Lam T.Y.2; Seto S.W.2; Au A.L.S.2; Poon C.C.W.2; Li R.W.S.2; Lam H.Y.2; Lau W.S.2; Chan S.W.3; Ngai S.M.1; Leung G.P.H.2; Lee S.M.Y.4; Tsui S.K.W.2; Kwan Y.W.2
2009-09-01
Source PublicationExperimental Biology and Medicine
ISSN15353702 15353699
Volume234Issue:9Pages:1047-1055
AbstractThe effects of folic acid (5.7 and 71 lg/kg, 4 weeks) consumption on the β-adrenoceptors (β-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of lean/control (+m/+db) and obese/diabetic (+db/+db) mice (female) were investigated. β-AR agonists (salbutamol, a β -AR agonist; BRL 37344 and CGP 12177, β -AR agonists; adrenaline, a β-AR agonist)-mediated lipolysis, β -, and β -ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the β-AR agonists-triggered lipolysis was observed in +db/+db mice, and folic acid supplementation (71 μg/kg) resulted in an improvement of both the baseline and the β-ARs-mediated lipolysis. In controls, a lower β - and β -ARs protein expression of the adipose tissues was detected in +db/+db mice, compared to +m/+db mice. In both strains fed with folic acid (71 μg/kg), a reduction of β -AR protein expression was observed compared to the respective controls. In +db/+db mice, folic acid (5.7 and 71 μg/kg) consumption caused a dose-dependent increase of β -AR protein expression compared to controls. We demonstrate that lipolysis elicited by β-AR (β - and β -ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on β-ARs protein expression and lipolysis. Copyright © 2009 by the Society for Experimental Biology and Medicine.
Keywordβ-adrenoceptor +db/+db mice Adipocytes Folic acid Lipolysis
DOI10.3181/0902-RM-44
URLView the original
Language英語
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chinese University of Hong Kong
2.The University of Hong Kong
3.Hong Kong Polytechnic University
4.University of Macau
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GB/T 7714
Lam T.Y.,Seto S.W.,Au A.L.S.,et al. Folic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice[J]. Experimental Biology and Medicine,2009,234(9):1047-1055.
APA Lam T.Y..,Seto S.W..,Au A.L.S..,Poon C.C.W..,Li R.W.S..,...&Kwan Y.W..(2009).Folic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice.Experimental Biology and Medicine,234(9),1047-1055.
MLA Lam T.Y.,et al."Folic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice".Experimental Biology and Medicine 234.9(2009):1047-1055.
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