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Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
Chan E.2; Liu X.-X.2; Guo D.-J.2; Kwan Y.-W.1; Leung G.P.-H.3; Lee S.M.-Y.4; Chan S.-W.2
2011-07-11
Source PublicationAmerican Journal of Chinese Medicine
ISSN0192415X
Volume39Issue:4Pages:693-704
AbstractIschemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company.
KeywordAntioxidant Activity Chinese Medicinal Herb Myocardial Ischemia-Reperfusion Injury Scutellaria baicalensis Georgi Total Flavonoid Content Total Phenol Content
DOI10.1142/S0192415X11009135
URLView the original
Language英語
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被引频次[WOS]:17   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题University of Macau
Affiliation1.Chinese University of Hong Kong
2.Hong Kong Polytechnic University
3.The University of Hong Kong
4.University of Macau
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Chan E.,Liu X.-X.,Guo D.-J.,et al. Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats[J]. American Journal of Chinese Medicine,2011,39(4):693-704.
APA Chan E..,Liu X.-X..,Guo D.-J..,Kwan Y.-W..,Leung G.P.-H..,...&Chan S.-W..(2011).Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats.American Journal of Chinese Medicine,39(4),693-704.
MLA Chan E.,et al."Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats".American Journal of Chinese Medicine 39.4(2011):693-704.
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