UM  > Institute of Chinese Medical Sciences
Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
Enoch Chan1; Xing-Xian Liu1; De-Jian Guo1; Yiu-Wa Kwan2; George Pak-Heng Leung3; Simon Ming-Yuen Lee4; Shun-Wan Chan2
2011-07-11
Source PublicationAmerican Journal of Chinese Medicine
ISSN0192415X
Volume39Issue:4Pages:693-704
Abstract

Ischemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity.

KeywordAntioxidant Activity Chinese Medicinal Herb Myocardial Ischemia-reperfusion Injury Scutellaria Baicalensis Georgi Total Flavonoid Content Total Phenol Content
DOI10.1142/S0192415X11009135
URLView the original
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000292205300006
Fulltext Access
Citation statistics
Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong
2.Institute of Vascular Medicine, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
3.Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong
4.Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomas Pereira S. J., Taipa, Macau, China
Recommended Citation
GB/T 7714
Enoch Chan,Xing-Xian Liu,De-Jian Guo,et al. Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats[J]. American Journal of Chinese Medicine,2011,39(4):693-704.
APA Enoch Chan.,Xing-Xian Liu.,De-Jian Guo.,Yiu-Wa Kwan.,George Pak-Heng Leung.,...&Shun-Wan Chan.(2011).Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats.American Journal of Chinese Medicine,39(4),693-704.
MLA Enoch Chan,et al."Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats".American Journal of Chinese Medicine 39.4(2011):693-704.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Enoch Chan]'s Articles
[Xing-Xian Liu]'s Articles
[De-Jian Guo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Enoch Chan]'s Articles
[Xing-Xian Liu]'s Articles
[De-Jian Guo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Enoch Chan]'s Articles
[Xing-Xian Liu]'s Articles
[De-Jian Guo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.