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Angelica sinensis isolate SBD.4: Composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans
Zhao H.4; Deneau J.4; Che G.O.L.3; Li S.3; Vagnini F.1; Azadi P.5; Sonon R.5; Ramjit R.2; Lee S.M.Y.3; Bojanowski K.4
2012
Source PublicationEuropean Journal of Dermatology
ISSN11671122 19524013
Volume22Issue:1Pages:58-67
Abstract

This report characterizes an aqueous isolate (SBD.4) of one of the most broadly used Chinese medicinal herbs, Angelica sinensis, from the perspective of its application in skin and wound care. SBD.4 has been chemically defined and was found to increase the strength of healed wounds in retired breeder (older) rats. Furthermore, the mechanism of action of this Angelica sinensis isolate was tested in the zebrafish angiogenesis model, and in human skin substitutes by DNA microarray, revealing a bioactivity profile consistent with skin repair and regeneration. When combined with several types of wound dressings, SBD.4 increased type I collagen production in human dermal fibroblasts, and when formulated in nanosilver hydrocolloid dressing, it was found effective in chronic ulcer management in humans, demonstrating that botanical high-tech wound dressings can be successfully developed to improve the treatment of chronic lesions in humans.

KeywordAngelica Sinensis Arginine Diabetes Skin Standardized Botanical Isolate Sucrose Ulcers
DOI10.1684/ejd.2011.1599
URLView the original
Indexed BySCI
WOS Research AreaDermatology
WOS SubjectDermatology
WOS IDWOS:000301818400013
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Heart Diabetes and Weight Loss Center
2.Euromed, Inc
3.Institute of Chinese Medical Sciences
4.Sunny BioDiscovery
5.The University of Georgia
Recommended Citation
GB/T 7714
Zhao H.,Deneau J.,Che G.O.L.,et al. Angelica sinensis isolate SBD.4: Composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans[J]. European Journal of Dermatology,2012,22(1):58-67.
APA Zhao H..,Deneau J..,Che G.O.L..,Li S..,Vagnini F..,...&Bojanowski K..(2012).Angelica sinensis isolate SBD.4: Composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans.European Journal of Dermatology,22(1),58-67.
MLA Zhao H.,et al."Angelica sinensis isolate SBD.4: Composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans".European Journal of Dermatology 22.1(2012):58-67.
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