UM  > 中華醫藥研究院
Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice
Zhang Z.3; Lai D.3; Wang L.1; Yu P.3; Zhu L.3; Guo B.3; Xu L.3; Zhou L.2; Sun Y.3; Lee S.M.Y.1; Wang Y.3
2014
Source PublicationPharmacology Biochemistry and Behavior
ISSN18735177 00913057
Volume122Pages:191-202
Abstract

The andrographolide-lipoic acid conjugate AL-1 is a newly synthesized molecule by covalently linking andrographolide (Andro) with α-lipoic acid (LA). In the present work, the neuroprotective effect of AL-1 was investigated in vitro and in a mouse model of the Parkinson's disease (PD). We found that AL-1 significantly prevented 1-methyl-4-phenylpyridinium (MPP )-induced neurotoxicity in SH-SY5Y cells and primary cerebellar granule neurons. In a mouse model of Parkinson's disease, AL-1 rescued 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced loss of tyrosine hydroxylase (TH)-positive neurons, improved the behavioral impairment, and elevated the striatal levels of dopamine and its metabolites 3,4-dihydroxyphenylacetic acid. Furthermore, AL-1 remarkably lowered the nitric oxide and malondialdehyde levels while increased the superoxide dismutase level in the substantial nigra of MPTP-treated mice. The immunoblotting data showed that AL-1 significantly ameliorated the decreased expression of TH protein in the substantial nigra and inhibited the up-regulation of phosphorylated NF-κB p65 in vitro and in vivo. Taken together, AL-1 exerted neuroprotective effect in vitro and in animal model of PD through anti-oxidation and inhibition of NF-κB activation. © 2014 Elsevier Inc. All rights reserved.

KeywordAndrographolide-lipoic Acid Conjugate Neuroprotection Nf-κb P65 Parkinson's Disease
DOI10.1016/j.pbb.2014.03.028
URLView the original
Indexed BySCI
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectBehavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000338597000022
Fulltext Access
Citation statistics
Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.University of Macau
2.Jinan University
3.Jinan University
Recommended Citation
GB/T 7714
Zhang Z.,Lai D.,Wang L.,et al. Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice[J]. Pharmacology Biochemistry and Behavior,2014,122:191-202.
APA Zhang Z..,Lai D..,Wang L..,Yu P..,Zhu L..,...&Wang Y..(2014).Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice.Pharmacology Biochemistry and Behavior,122,191-202.
MLA Zhang Z.,et al."Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice".Pharmacology Biochemistry and Behavior 122(2014):191-202.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang Z.]'s Articles
[Lai D.]'s Articles
[Wang L.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang Z.]'s Articles
[Lai D.]'s Articles
[Wang L.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang Z.]'s Articles
[Lai D.]'s Articles
[Wang L.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.