UM  > 中華醫藥研究院
New perspective on the dual functions of indirubins in cancer therapy and neuroprotection
Wang Y.; Hoi P.M.; Chan J.Y.-W.; Lee S.M.-Y.
2014-03-01
Source PublicationAnti-Cancer Agents in Medicinal Chemistry
ISSN18755992 18715206
Volume14Issue:9Pages:1213-1219
Abstract

Indirubin is an active ingredient mainly used to treat leukemia in China and is reported to be a leading inhibitor of cyclindependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) by competing with ATP binding sites. New findings have indicated that its comprehensive structure may contribute to its polypharmacological activities particularly in cancer and neurodegenerative disease therapy, as both of these diseases are usually accompanied by a common molecular link related to abnormal phosphorylation of CDKs and GSK-3. In the elderly, cancer and neurodegenerative disease are tightly associated common diseases and sometimes unavoidably coexist. In this review, the underlying mechanisms of the dual actions of indirubin and its structurally-related compounds in cancer and neurodegenerative disease therapy are presented.

KeywordCancer Cdks Dual Function Gsk-3 Indirubin Neurodegeneration
DOI10.2174/1871520614666140825112924
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Pharmacology & Pharmacy
WOS SubjectOncology ; Chemistry, Medicinal
WOS IDWOS:000344150100003
全文获取链接
引用统计
被引频次[WOS]:7   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences
First Author AffilicationInstitute of Chinese Medical Sciences
推荐引用方式
GB/T 7714
Wang Y.,Hoi P.M.,Chan J.Y.-W.,et al. New perspective on the dual functions of indirubins in cancer therapy and neuroprotection[J]. Anti-Cancer Agents in Medicinal Chemistry,2014,14(9):1213-1219.
APA Wang Y.,Hoi P.M.,Chan J.Y.-W.,&Lee S.M.-Y..(2014).New perspective on the dual functions of indirubins in cancer therapy and neuroprotection.Anti-Cancer Agents in Medicinal Chemistry,14(9),1213-1219.
MLA Wang Y.,et al."New perspective on the dual functions of indirubins in cancer therapy and neuroprotection".Anti-Cancer Agents in Medicinal Chemistry 14.9(2014):1213-1219.
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
Google Scholar
中相似的文章 Google Scholar
[Wang Y.]的文章
[Hoi P.M.]的文章
[Chan J.Y.-W.]的文章
Baidu academic
中相似的文章 Baidu academic
[Wang Y.]的文章
[Hoi P.M.]的文章
[Chan J.Y.-W.]的文章
Bing Scholar
中相似的文章 Bing Scholar
[Wang Y.]的文章
[Hoi P.M.]的文章
[Chan J.Y.-W.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。