UM  > 中華醫藥研究院
A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells
Liang Wang2; Xiaojing Zhang3; Judy Yuet‐Wa Chan2; Luchen Shan3; Guozhen Cui2; Qingbin Cui3; Yingfei Wang3; Jingjing Li2; Huanxian Chen2; Qingwen Zhang2; Pei Yu3; Yifan Han1; Yuqiang Wang3; Simon Ming‐Yuen Lee2
2016
Source PublicationJournal of Cellular Biochemistry
ISSN10974644 07302312
Volume117Issue:1Pages:94-105
Abstract

Doxorubicin (Dox) is an anthracycline antibiotic widely used in clinics as an anticancer agent. However, the use of Dox is limited by its cardiotoxicity. We have previously shown that a Danshensu (DSS) derivative, ADTM, displayed strong cardioprotective effects. With improved chemical stability and activity, a novel DSS derivative, D006, based on the structure of ADTM, was synthesized. In the present study, the protective effects of D006, indexed by attenuation of the cardiotoxicity induced by Dox as well as chemosensitizing effects that increase the antitumor activity of Dox, were investigated. Our results showed that D006 was more potent than either parental compound, or their use in combination, in ameliorating Dox-induced toxicity in H9c2 cells. In our zebrafish model, D006, but not DSS, alone significantly preserved the ventricular function of zebrafish after Dox treatment. Moreover, D006 upregulated mitochondrial biogenesis and increased mtDNA copy number after Dox treatment of H9c2 cells. D006 promoted the expression of HO-1 protein in a time-dependent manner while the HO-1 inhibitor, Znpp, reversed the protective effects of D006. In human breast tumor MCF-7 cells, D006 enhanced Dox-induced cytotoxicity by increasing apoptosis. In conclusion, our results indicate that a new DSS derivative exhibits promising protective effects against Dox-induced cardiotoxicity both in vivo and in vitro, an effect at least partially mediated by induction of HO-1 expression and the activation of mitochondrial biogenesis. Meanwhile, D006 also potentiated the anti-cancer effects of Dox in breast tumor cells. J. Cell. Biochem. 117: 94-105, 2016.

KeywordBreast Cancer Cardiotoxicity Doxorubicin Mitochondrial Biogenesis
DOI10.1002/jcb.25253
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000368229800010
Fulltext Access
Citation statistics
Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLuchen Shan; Simon Ming‐Yuen Lee
Affiliation1.Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, Hong Kong Polytechnic University, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.Institute of New Drug Research, College of Pharmacy, Jinan University, Guangzhou, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liang Wang,Xiaojing Zhang,Judy Yuet‐Wa Chan,et al. A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells[J]. Journal of Cellular Biochemistry,2016,117(1):94-105.
APA Liang Wang.,Xiaojing Zhang.,Judy Yuet‐Wa Chan.,Luchen Shan.,Guozhen Cui.,...&Simon Ming‐Yuen Lee.(2016).A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells.Journal of Cellular Biochemistry,117(1),94-105.
MLA Liang Wang,et al."A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells".Journal of Cellular Biochemistry 117.1(2016):94-105.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liang Wang]'s Articles
[Xiaojing Zhang]'s Articles
[Judy Yuet‐Wa Chan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liang Wang]'s Articles
[Xiaojing Zhang]'s Articles
[Judy Yuet‐Wa Chan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liang Wang]'s Articles
[Xiaojing Zhang]'s Articles
[Judy Yuet‐Wa Chan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.