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The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides
Chen Huang2; Jean-Étienne RL Morlighem1; Hefeng Zhou2; Érica P Lima3; Paula B Gomes4; Jing Cai2; Inchio Lou2; Carlos D Pérez3; Simon Ming Lee2; Gandhi Rádis-Baptista1
2016
Source PublicationGenome Biology and Evolution
ISSN17596653
Volume8Issue:9Pages:3045-3064
Abstract

Protopalythoa is a zoanthid that, together with thousands of predominantly marine species, such as hydra, jellyfish, and sea anemones, composes the oldest eumetazoan phylum, i.e., the Cnidaria. Some of these species, such as sea wasps and sea anemones, are highly venomous organisms that can produce deadly toxins for preying, for defense or for territorial disputes. Despite the fact that hundreds of organic and polypeptide toxins have been characterized from sea anemones and jellyfish, practically nothing is known about the toxin repertoire in zoanthids. Here, based on a transcriptome analysis of the zoanthid Protopalythoa variabilis, numerous predicted polypeptides with canonical venom protein features are identified. These polypeptides comprise putative proteins from different toxin families: neurotoxic peptides,hemostatic andhemorrhagic toxins,membrane-Active (pore-forming) proteins,protease inhibitors, mixed-function venom enzymes, and venom auxiliary proteins. The synthesis and functional analysis of two of these predicted toxin products, one related to the ShK/Aurelin family and the other to a recently discovered anthozoan toxin, displayed potent in vivo neurotoxicity that impaired swimming in larval zebrafish. Altogether, the complex array of venom-related transcripts that are identified in P. variabilis, some ofwhich are first reported inCnidaria, provides novel insight into the toxin distribution among species and might contribute to the understanding of composition and evolution of venom polypeptides in toxiferous animals.

KeywordHexacorallia Molecular Toxinology Peptide Toxin Rna-seq Transcriptome Venomics Zoanthidea
DOI10.1093/gbe/evw204
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaEvolutionary Biology ; Genetics & Heredity
WOS SubjectEvolutionary Biology ; Genetics & Heredity
WOS IDWOS:000386122800012
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSimon Ming Lee; Gandhi Rádis-Baptista
Affiliation1.Universidade Federal do Ceara
2.University of Macau
3.Universidade Federal de Pernambuco
4.Universidade Federal Rural de Pernambuco
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chen Huang,Jean-Étienne RL Morlighem,Hefeng Zhou,et al. The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides[J]. Genome Biology and Evolution,2016,8(9):3045-3064.
APA Chen Huang.,Jean-Étienne RL Morlighem.,Hefeng Zhou.,Érica P Lima.,Paula B Gomes.,...&Gandhi Rádis-Baptista.(2016).The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides.Genome Biology and Evolution,8(9),3045-3064.
MLA Chen Huang,et al."The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides".Genome Biology and Evolution 8.9(2016):3045-3064.
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