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Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs
JingjingLia1; YuranPeng2; Shang Li1; Yicheng Sun2; Judy Yuet-Wa Chan1; Guozhen Cui1; Decai Wang2; Guo-Chun Zhou2; Simon Ming-Yuen Lee1
2016
Source PublicationEuropean Journal of Pharmacology
ISSN18790712 00142999
Volume789Pages:344-353
Abstract

Andrographolide is among the most promising anti-tumor and anti-angiogenic components in Andrographis paniculata but its poor bioavailability and limited efficacy pose difficulties for its therapeutic development. Therefore, improving its pharmaceutical features and potency, by modifying its chemical structure, is desirable. In the present study, a new andrographolide derivative (AGP-40) was synthesized and characterized for its anti-angiogenic properties. Human umbilical vein endothelial cells (HUVECs) and zebrafish models were used to identify the anti-angiogenic activity of AGP-40. AGP-40 significantly suppressed the formation of blood vessels in zebrafish and inhibited proliferation, migration and tube formation in vitro. The anti-angiogenic effects of AGP-40 are at least partially mediated via the PI3K/Akt and MEK/Erk(1/2) signaling pathways. Furthermore, AGP-40 exhibited stronger anti-proliferative effects than andrographolide against A549, HepG2, Hela cancer cell lines. This study is the first to demonstrate the promising anti-angiogenic activity of the new andrographolide derivative AGP-40. Our results indicate that AGP-40 could serve as a potential therapeutic agent for the treatment and prevention of diseases associated with excessive angiogenesis.

KeywordAndrographolide Angiogenesis Zebrafish
DOI10.1016/j.ejphar.2016.07.043
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000385327500040
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
JingjingLia,YuranPeng,Shang Li,et al. Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs[J]. European Journal of Pharmacology,2016,789:344-353.
APA JingjingLia.,YuranPeng.,Shang Li.,Yicheng Sun.,Judy Yuet-Wa Chan.,...&Simon Ming-Yuen Lee.(2016).Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs.European Journal of Pharmacology,789,344-353.
MLA JingjingLia,et al."Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs".European Journal of Pharmacology 789(2016):344-353.
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