UM  > Institute of Chinese Medical Sciences
Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells
Chi Teng Vong2; Hisa Hui Ling Tseng2; Yiu Wa Kwan1; Simon Ming-Yuen Lee2; Maggie Pui Man Hoi2
2016-03-21
Source PublicationFrontiers in Pharmacology
ISSN16639812
Volume7Issue:MAR
Abstract

Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction. During chronic ER stress, misfolded proteins accumulate and initiate β-cell apoptosis. Moreover, β-cell dysfunction leads to defect in insulin secretion, which is the key process in the development and progression of T2DM. Therefore, the aim of the present study was to examine the effects of A. camphorata on insulin secretion and ER stress-induced apoptosis in a mouse β-cell line, MIN6, and their underlying mechanisms. We demonstrated that the ethanolic extract of A. camphorata increased glucose-induced insulin secretion dose-dependently through peroxisome proliferator-activated receptor-γ (PPAR-γ) pathway, and upregulated genes that were involved in insulin secretion, including PPAR-γ, glucose transporter-2 and glucokinase. Furthermore, A. camphorata slightly increased cell proliferation, as well as protected from ER stress-induced apoptosis in MIN6 cells. In conclusion, this study provided evidences that A. camphorata might have anti-diabetic effects and could be a novel drug for T2DM.

KeywordAntrodia Camphorata Insulin Secretion Pancreatic Β-cell Death Ppar-γ Type 2 Diabetes Mellitus
DOI10.3389/fphar.2016.00067
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000372359400001
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chi Teng Vong,Hisa Hui Ling Tseng,Yiu Wa Kwan,et al. Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells[J]. Frontiers in Pharmacology,2016,7(MAR).
APA Chi Teng Vong,Hisa Hui Ling Tseng,Yiu Wa Kwan,Simon Ming-Yuen Lee,&Maggie Pui Man Hoi.(2016).Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells.Frontiers in Pharmacology,7(MAR).
MLA Chi Teng Vong,et al."Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells".Frontiers in Pharmacology 7.MAR(2016).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chi Teng Vong]'s Articles
[Hisa Hui Ling Tseng]'s Articles
[Yiu Wa Kwan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chi Teng Vong]'s Articles
[Hisa Hui Ling Tseng]'s Articles
[Yiu Wa Kwan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chi Teng Vong]'s Articles
[Hisa Hui Ling Tseng]'s Articles
[Yiu Wa Kwan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.