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Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells
Vong C.T.2; Tseng H.H.L.2; Kwan Y.W.1; Lee S.M.-Y.2; Hoi M.P.M.2
2016-03-21
Source PublicationFrontiers in Pharmacology
ISSN16639812
Volume7Issue:MAR
Abstract

Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction. During chronic ER stress, misfolded proteins accumulate and initiate β-cell apoptosis. Moreover, β-cell dysfunction leads to defect in insulin secretion, which is the key process in the development and progression of T2DM. Therefore, the aim of the present study was to examine the effects of A. camphorata on insulin secretion and ER stress-induced apoptosis in a mouse β-cell line, MIN6, and their underlying mechanisms. We demonstrated that the ethanolic extract of A. camphorata increased glucose-induced insulin secretion dose-dependently through peroxisome proliferator-activated receptor-γ (PPAR-γ) pathway, and upregulated genes that were involved in insulin secretion, including PPAR-γ, glucose transporter-2 and glucokinase. Furthermore, A. camphorata slightly increased cell proliferation, as well as protected from ER stress-induced apoptosis in MIN6 cells. In conclusion, this study provided evidences that A. camphorata might have anti-diabetic effects and could be a novel drug for T2DM.

KeywordAntrodia Camphorata Insulin Secretion Pancreatic Β-cell Death Ppar-γ Type 2 Diabetes Mellitus
DOI10.3389/fphar.2016.00067
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000372359400001
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chinese University of Hong Kong
2.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Vong C.T.,Tseng H.H.L.,Kwan Y.W.,et al. Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells[J]. Frontiers in Pharmacology,2016,7(MAR).
APA Vong C.T.,Tseng H.H.L.,Kwan Y.W.,Lee S.M.-Y.,&Hoi M.P.M..(2016).Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells.Frontiers in Pharmacology,7(MAR).
MLA Vong C.T.,et al."Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells".Frontiers in Pharmacology 7.MAR(2016).
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