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Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B
Guo B.2; Zheng C.2; Cai W.2; Cheng J.2; Wang H.2; Li H.4; Sun Y.2; Cui W.3; Wang Y.2; Han Y.1; Lee S.M.-Y.4; Zhang Z.2
2016-07-06
Source PublicationJournal of Agricultural and Food Chemistry
ISSN15205118 00218561
Volume64Issue:26Pages:5324-5333
AbstractChrysin, a flavonoid compound existing in several plants, is applied as a dietary supplement because of its beneficial effects on general human health and alleviation of neurological disorders. However, mechanisms underlying neuroprotection of chrysin has not been fully elucidated, and the effects of chrysin on the Parkinson's disease (PD) model in vivo have not been investigated. It is here shown that chrysin protects primary granular neurons against 1-methyl-4-phenylpyridinium ion insult via antiapoptosis by reversing the dysregulated expression of Bcl-2, Bax, and caspase 3. The mechanisms also involved activating transcriptional factor myocyte enhancer factor 2D (MEF2D) via regulation of AKT-GSK3β signaling. In this in vivo model of PD, chrysin rescued the dopaminergic neurons loss and alleviated the decrease in dopamine level induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Moreover, chrysin markedly inhibited monoamine oxidase-B activity in vitro and in vivo. In conclusion, chrysin exerts beneficial effects to PD, possibly through multitarget mechanisms including antineuronal apoptosis, activation of the AKT-GSK3β/MEF2D pathway, and inhibition of the MAO-B activity.
Keywordchrysin MAO-B MEF2D neuroprotection Parkinson's disease
DOI10.1021/acs.jafc.6b01707
URLView the original
Language英語
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong Polytechnic University
2.Jinan University
3.Ningbo University
4.University of Macau
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Guo B.,Zheng C.,Cai W.,et al. Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B[J]. Journal of Agricultural and Food Chemistry,2016,64(26):5324-5333.
APA Guo B..,Zheng C..,Cai W..,Cheng J..,Wang H..,...&Zhang Z..(2016).Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B.Journal of Agricultural and Food Chemistry,64(26),5324-5333.
MLA Guo B.,et al."Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B".Journal of Agricultural and Food Chemistry 64.26(2016):5324-5333.
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